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SRP6285

Sigma-Aldrich

PCSK9 human

recombinant, expressed in HEK 293 cells, ≥97% (SDS-PAGE)

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Synonym(s):
FNDC5 (cleaved), Fibronectin Type III Domain-containing Protein 5 (cleaved), Fibronectin Type III Repeat-containing Protein 2 (cleaved)
NACRES:
NA.32

biological source

human

recombinant

expressed in HEK 293 cells

tag

6-His tagged (C-terminus)

Assay

≥97% (SDS-PAGE)

form

lyophilized powder

mol wt

calculated mol wt 75.1 kDa
observed mol wt 20 kDa (DTT-reduced. Protein migrates due to glycosylation and proteolytic digestion.Gln 31 is the predicted N-terminus.)
observed mol wt 62 kDa

packaging

pkg of 20 μg

impurities

<1 EU/μg endotoxin (LAL test)

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... PCSK9(255738)

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This Item
SAB2501521ABS1006SRP6291
PCSK9 human recombinant, expressed in HEK 293 cells, &#8805;97% (SDS-PAGE)

Sigma-Aldrich

SRP6285

PCSK9 human

Anti-PCSK9 Antibody from rabbit, purified by affinity chromatography

Sigma-Aldrich

ABS1006

Anti-PCSK9 Antibody

IFN-&#969; human recombinant, expressed in HEK 293 cells, &#8805;93% (SDS-PAGE)

Sigma-Aldrich

SRP6291

IFN-ω human

recombinant

expressed in HEK 293 cells

recombinant

-

recombinant

-

recombinant

expressed in HEK 293 cells

assay

≥97% (SDS-PAGE)

assay

-

assay

-

assay

≥93% (SDS-PAGE)

form

lyophilized powder

form

buffered aqueous solution

form

-

form

lyophilized powder

mol wt

calculated mol wt 75.1 kDa, observed mol wt 20 kDa (DTT-reduced. Protein migrates due to glycosylation and proteolytic digestion.Gln 31 is the predicted N-terminus.), observed mol wt 62 kDa

mol wt

-

mol wt

-

mol wt

calculated mol wt 16.8 kDa (no tag), observed mol wt 25.0 kDa (DTT-reduced. Protein migrates due to glycosylation. Gln 24 is the predicted N-terminus.)

packaging

pkg of 20 μg

packaging

-

packaging

-

packaging

pkg of 10 μg

General description

Proprotein convertase subtilisin/kexin type 9 (PCSK9), is an enzyme which in humans is encoded by the PCSK9 gene. This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).

Physical form

Sterile filtered through a 0.22 micron filter. Lyophilized from 1 x PBS, pH 7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 100 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3


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