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SRP6291

Sigma-Aldrich

IFN-ω human

recombinant, expressed in HEK 293 cells, ≥93% (SDS-PAGE)

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Synonym(s):
IFI, IFNG
NACRES:
NA.32

biological source

human

recombinant

expressed in HEK 293 cells

Assay

≥93% (SDS-PAGE)

form

lyophilized powder

mol wt

calculated mol wt 16.8 kDa (no tag)
observed mol wt 25.0 kDa (DTT-reduced. Protein migrates due to glycosylation. Gln 24 is the predicted N-terminus.)

packaging

pkg of 10 μg

impurities

<1 EU/μg endotoxin (LAL test)

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

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MSST0040SRP6396RAB0924
IFN-&#969; human recombinant, expressed in HEK 293 cells, &#8805;93% (SDS-PAGE)

Sigma-Aldrich

SRP6291

IFN-ω human

recombinant

expressed in HEK 293 cells

recombinant

expressed in HEK 293 cells

recombinant

expressed in HEK 293 cells

recombinant

-

assay

≥93% (SDS-PAGE)

assay

≥98% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

assay

-

form

lyophilized powder

form

lyophilized powder

form

lyophilized

form

-

mol wt

calculated mol wt 16.8 kDa (no tag), observed mol wt 25.0 kDa (DTT-reduced. Protein migrates due to glycosylation. Gln 24 is the predicted N-terminus.)

mol wt

calculated mol wt 17 kDa

mol wt

calculated mol wt 20.2 kDa, observed mol wt 23-33 kDa (DTT-reduced. Protein migrates due to different glycosylation. Ala 46 is the predicted N-terminus.)

mol wt

-

packaging

pkg of 10 μg

packaging

-

packaging

pkg of 10 and 50 μg

packaging

kit of 96 wells (12 strips x 8 wells)

General description

Interferon-gamma (IFN-γ/IFNG) is a dimerized soluble cytokine that is the only member of the type II class of interferon. This interferon was originally called macrophage-activating factor, a term now used to describe a larger family of proteins to which IFN-γ belongs. IFN-gamma has been used in a wide variety of clinical indications. Interferon-gamma (IFN gamma) is a central regulator of the immune response and signals via the Janus Activated Kinase (JAK)-Signal Transducer and Activator of Transcription (STAT) pathway. Interferon gamma has broader roles in activation of innate and adaptive immune responses to viruses and tumors, in part through upregulating transcription of genes involved in cell cycle regulation, apoptosis, and antigen processing/presentation. Despite this, rodent and human trophoblast cells show dampened responses to IFNG that reflect the resistance of these cells to IFNG-mediated activation of major histocompatibility complex (MHC) class II transplantation antigen expression.

Physical form

Lyophilized from 0.22 μm filtered solution in 20 mM Tris, 100 mM NaCl, pH 8.0. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in sterile deionized water to a concentration of 100 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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