SRP6302

Apolipoprotein B from human plasma

≥95% (SDS-PAGE)

• Synonym(s): Apo-B
• NACRES: NA.32

Properties

• biological source: human plasma
• Assay: ≥95% (SDS-PAGE)
• form: lyophilized
• mol wt: 550 kDa
• packaging: pkg of 500 μg
• UniProt accession no.: P04114
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... ApoB(338)

Description

General description

Apolipoprotein B is the dominant protein constituent of low-density lipoprotein (LDL). The concentration of Apo B in normal plasma is 90mg/100mL. Two forms of Apo B exist: Apo B-100 and Apo B-48. The first is found in VLDL and LDL and is produced by the liver. The second is found in chylomicrons and originates in the intestine. The gene encoding this protein is localized on chromosome 2p24.1.

Biochem/physiol Actions

Apo B is thought to stabilize lipid emulsions, serve as a cofactor and modulator of enzymatic reactions, manage export of lipids out of cells and direct lipids to target organs. Apo B levels are positively correlated with the risk of coronary disease. Apo B levels may be a more sensitive predictor of cardiovascular risk than LDL levels and do not involve fasting for accurate measurement. Mutations in this gene or its regulatory region cause hypoβ-lipoproteinemia, normotriglyceridemic and hypercholesterolemia due to ligand-defective ApoB, diseases affecting plasma cholesterol and ApoB levels.

Physical form

Lyophilized from 10 mM Na deoxycholate, pH 10.0, with 50 mM Na2CO3 and 50 mM NaCI.

Reconstitution

In water or aqueous buffer

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable