Skip to Content
MilliporeSigma
All Photos(1)

Documents

SRP6302

Sigma-Aldrich

Apolipoprotein B from human plasma

≥95% (SDS-PAGE)

Synonym(s):

Apo-B

Sign Into View Organizational & Contract Pricing


About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human plasma

assay

≥95% (SDS-PAGE)

form

lyophilized

mol wt

550 kDa

packaging

pkg of 500 μg

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... ApoB(338)

General description

Apolipoprotein B is the dominant protein constituent of low-density lipoprotein (LDL). The concentration of Apo B in normal plasma is 90mg/100mL. Two forms of Apo B exist: Apo B-100 and Apo B-48. The first is found in VLDL and LDL and is produced by the liver. The second is found in chylomicrons and originates in the intestine. The gene encoding this protein is localized on chromosome 2p24.1.

Biochem/physiol Actions

Apo B is thought to stabilize lipid emulsions, serve as a cofactor and modulator of enzymatic reactions, manage export of lipids out of cells and direct lipids to target organs. Apo B levels are positively correlated with the risk of coronary disease. Apo B levels may be a more sensitive predictor of cardiovascular risk than LDL levels and do not involve fasting for accurate measurement. Mutations in this gene or its regulatory region cause hypoβ-lipoproteinemia, normotriglyceridemic and hypercholesterolemia due to ligand-defective ApoB, diseases affecting plasma cholesterol and ApoB levels.

Physical form

Lyophilized from 10 mM Na deoxycholate, pH 10.0, with 50 mM Na2CO3 and 50 mM NaCI.

Reconstitution

In water or aqueous buffer

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Mechanisms of disease: genetic causes of familial hypercholesterolemia.
Soutar AK and Naoumova RP
Nature Clinical Practice. Cardiovascular Medicine, 4(4), 214-225 (2007)
Apolipoprotein B, the major protein component of triglyceride-rich and low density lipoproteins.
Chan L
The Journal of Biological Chemistry, 267(36), 25621-25624 (1992)
Low-density lipoprotein cholesterol, apolipoprotein B, and risk of coronary heart disease: from familial hyperlipidemia to genomics.
Imes CC and Austin MA
Biological Research for Nursing, 15(3), 292-308 (2013)
Meta-analysis of four new genome scans for lipid parameters and analysis of positional candidates in positive linkage regions.
Heijmans BT
European Journal of Human Genetics, 13(10), 1143-1153 (2005)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service