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SRP6313

Sigma-Aldrich

Alpha 2 Antiplasmin from human plasma

≥95% (SDS-PAGE)

Synonym(s):
AAP, Alpha-2-plasmin inhibitor, PLI, SERPINF2
NACRES:
NA.32

biological source

human

Assay

≥95% (SDS-PAGE)

form

lyophilized

potency

≥5.0 I.U. per mg

mol wt

70 kDa

packaging

pkg of 100 μg

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... SERPINF2(5345)

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This Item
SAB1406264A8849SRP6316
assay

≥95% (SDS-PAGE)

assay

-

assay

-

assay

≥95% (SDS-PAGE)

form

lyophilized

form

buffered aqueous solution

form

lyophilized powder

form

lyophilized

potency

≥5.0 I.U. per mg

potency

-

potency

-

potency

-

mol wt

70 kDa

mol wt

antigen ~54.6 kDa

mol wt

-

mol wt

58 kDa

packaging

pkg of 100 μg

packaging

-

packaging

vial of ≥0.5 mg (Protein based on E1%/280 = 6.7)

packaging

pkg of 100 μg, pkg of 500 μg

General description

α-2 antiplasmin (AAP) is a member of the Serpin superfamily. Liver and kidney are major sites of its production and other tissues such as muscle, intestine, central nervous system, and placenta also express its mRNA at a moderate level. The tissue expression pattern indicates that it is a key regulator of plasmin mediated proteolysis in these tissues. The gene encoding this protein is localized on human chromosome 17.
α-2 antiplasmin (AAP) is a member of the Serpin superfamily. Liver and kidney are major sites of its production and other tissues such as muscle, intestine, central nervous system, and placenta also express its mRNA at a moderate level. The tissue expression pattern indicates that it is a key regulator of plasmin mediated proteolysis in these tissues. The AAP gene is mapped to human chromosome 17p13 and codes for a glycoprotein of single chain containing 464 amino acid residues.

Biochem/physiol Actions

α-2 antiplasmin (AAP) is the primary physiological inhibitor of the serine protease plasmin, which is responsible for the dissolution of fibrin clots. In addition to plasmin, it is also an efficient inhibitor of trypsin and chymotrypsin. α-antiplasmin-deficiency is a rare coagulation disorder which allows unrestrained fibrinolytic activity. Individuals with this condition may receive therapeutic A2AP prior to surgery to prevent postoperative hemorrhaging.
α-2 antiplasmin (AAP) is the primary physiological inhibitor of the serine protease plasmin, which is responsible for the dissolution of fibrin clots. It inhibits the action of protease by the formation In addition to plasmin, it is also an efficient inhibitor of trypsin and chymotrypsin. α-antiplasmin-deficiency is a rare coagulation disorder which allows unrestrained fibrinolytic activity. AAP is known to inhibit fibrinogenolysis by preventing free plasmin circulation.

Physical form

Lyophilized from 20 mM Bis-Tris, pH 6.4, with 200 mM NaCl.

Reconstitution

In water or aqueous buffer

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3


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