The product labeled as number 6315 corresponds to SRP6315 Alpha 2 Macroglobulin, Fast Form derived from human plasma. This product specifically contains the fast form of the protein. On the other hand, product number 6314 corresponds to SRP6314 Alpha 2 Macroglobulin from human plasma, which is a mixture of the slow and fast forms of the protein.
SRP6314
Alpha 2 Macroglobulin from human plasma
≥95% (SDS-PAGE)
Synonym(s):
A2M, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5, CPAMD5, FWP007
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352202
Biological source:
human
Assay:
≥95% (SDS-PAGE)
Form:
lyophilized
Mol wt:
725 kDa (Homotetramer Subunit size: 180 kDa)
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General description
Biochem/physiol Actions
α 2 macroglobulin (A2M) functions as a broad-spectrum protease-binding protein. It is a large plasma glycoprotein that has long been known as an irreversible inhibitor of a variety of proteinases. More recently, it has been reported that numerous growth factors, cytokines and hormones bind to α 2M through diverse mechanisms. A2M is also produced in the brain where it binds multiple extracellular ligands and is internalized by neurons and astrocytes. In the brain of Alzheimer′s disease (AD) patients, A2M has been localized to diffuse amyloid plaques. A2M also binds soluble β-amyloid, of which it mediates degradation.[1][2] Clinically, levels are increased in liver cirrhosis, nephrotic syndrome, diabetes, and severe burn cases.
Physical form
Lyophilized from 30 mM Na Phosphate, pH 7.0, with glycine as a stabilizer.
Preparation Note
In water or aqueous buffer
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Interleukin-6 and alpha-2-macroglobulin indicate an acute-phase state in Alzheimer's disease cortices.
Bauer J
Febs Letters, 285, 111-114 (1991)
The interaction of alpha 2-macroglobulin with proteinases. Characteristics and specificity of the reaction, and a hypothesis concerning its molecular mechanism.
Barrett AJ and Starkey PM
The Biochemical Journal, 133, 709-724 (1973)
Jennifer L Robinson et al.
Scientific reports, 8(1), 8527-8527 (2018-06-06)
Temporomandibular joint degenerative disease (TMJ-DD) is a chronic form of TMJ disorder that specifically afflicts people over the age of 40 and targets women at a higher rate than men. Prevalence of TMJ-DD in this population suggests that estrogen loss
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Q: Is product number 6314 considered slow A2M (i.e., it has not trapped a protease) since you list product number 6315 as fast alpha-2-macroglobulin (i.e., it has trapped a protease)?
1 answer-
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How many mg of alpha-2 macroglobulin in 1 (one) IU?
1 answer-
This product is supplied as a 1 mg package. The material is not tested for potency or activity. The minimum purity specification is 95% by SDS-PAGE.
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