SRP6314

Alpha 2 Macroglobulin from human plasma

≥95% (SDS-PAGE)

• Synonym(s): A2M, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5, CPAMD5, FWP007
• NACRES: NA.32

Properties

• biological source: human
• Assay: ≥95% (SDS-PAGE)
• form: lyophilized
• mol wt: 725 kDa (Homotetramer Subunit size: 180 kDa)
• packaging: pkg of 1 mg
• UniProt accession no.: P01023
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... A2M(2)

Description

General description

α 2 macroglobulin (A2M) is a major serum protein found at concentrations of 240 mg/100 mL in men and 290 mg/100 mL in women. It is produced by the liver, and is a major component of the α-2 band in protein electrophoresis. It has a molecular weight of 800,000 Da.

Biochem/physiol Actions

α 2 macroglobulin (A2M) functions as a broad-spectrum protease-binding protein. It is a large plasma glycoprotein that has long been known as an irreversible inhibitor of a variety of proteinases. More recently, it has been reported that numerous growth factors, cytokines and hormones bind to α 2M through diverse mechanisms. A2M is also produced in the brain where it binds multiple extracellular ligands and is internalized by neurons and astrocytes. In the brain of Alzheimer′s disease (AD) patients, A2M has been localized to diffuse amyloid plaques. A2M also binds soluble β-amyloid, of which it mediates degradation. Clinically, levels are increased in liver cirrhosis, nephrotic syndrome, diabetes, and severe burn cases.

Physical form

Lyophilized from 30 mM Na Phosphate, pH 7.0, with glycine as a stabilizer.

Reconstitution

In water or aqueous buffer

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable