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SRP6494

Sigma-Aldrich

IL 13RA2/CD213 human

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

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Synonym(s):
CD213α2, CD213A2, CT-19, CT19, IL-13BP, IL-13R, IL-13Rα2, IL-13RA2, IL13BP
NACRES:
NA.32

biological source

human

recombinant

expressed in HEK 293 cells

assay

≥95% (SDS-PAGE)

form

lyophilized

mol wt

calculated mol wt 63.2 kDa (This protein is fused with Fc region of human IgG1 at the C-terminus.)
observed mol wt 80-90 kDa by SDS-PAGE (reducing) (Asp27 is the predicted N-terminal .)

packaging

pkg of 20 and 100 μg

impurities

<1 EU/μg endotoxin (LAL test)

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... IL13RA2(3598)

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This Item
SRP6362SAB1406031WH0003598M1
vibrant-m

SRP6494

IL 13RA2/CD213 human

vibrant-m

SRP6362

IL13RA2 human

assay

≥95% (SDS-PAGE)

assay

≥85% (SDS-PAGE)

assay

-

assay

-

biological source

human

biological source

human

biological source

mouse

biological source

mouse

storage temp.

−20°C

storage temp.

−70°C

storage temp.

−20°C

storage temp.

−20°C

mol wt

calculated mol wt 63.2 kDa (This protein is fused with Fc region of human IgG1 at the C-terminus.), observed mol wt 80-90 kDa by SDS-PAGE (reducing) (Asp27 is the predicted N-terminal .)

mol wt

39.5 kDa (340 aa, 27-343 aa + His Tag)

mol wt

antigen ~44.2 kDa

mol wt

-

Gene Information

human ... IL13RA2(3598)

Gene Information

human ... IL13RA2(3598)

Gene Information

human ... IL13RA2(3598)

Gene Information

human ... IL13RA2(3598)

General description

Interleukin-13 receptor subunit α-2, also known as IL13Rα2, IL13Ra2 cluster of differentiation 213A2, CD213A2, CT19, IL-13R, IL13BP, and is a membrane bound protein that in humans is encoded by the IL13RA2 gene. IL13Rα2 is closely related to IL13Rα1, a subunit of the interleukin-13 receptor complex. This protein binds IL13 with high affinity, but lacks any significant cytoplasmic domain, and does not appear to function as a signal mediator. It is, however able to regulate the effects of both IL13 and IL4, despite the fact it is unable to bind directly to the latter. It is also reported to play a role in the internalization of IL13. IL13Rα2 is a component of the cell surface receptors, however, the majority exists in intracellular pools and in soluble form, and thus plays an opposite role as a potent IL13 antagonist compared with IL13Rα1. It also functions as an inhibitor of IL4-dependent pathway probably through the physical interaction between the short intracellular domain of and cytoplasmic domain of IL13Rα2 and the IL4Rα chain. In spite of the failed STAT signaling function, IL13Rα2 dose induce TGF-β production and fibrosis. Additionally, IL13Rα2has been reported to be abundantly and specifically overexpressed in glioblastoma multiforme.

Physical form

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM glycine, pH 7.0. Normally Mannitol or Trehalose is added as protectants before lyophilization.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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