This haptoglobin product is lyophilized from a solution containing 0.269 % Trehalose, 0.727 % Dibasic mono hydrogen potassium phosphate, and 0.248 % Monobasic dihydrogen potassium phosphate.
SRP6507
Haptoglobin (Phenotype 1-1) from human plasma
≥95% (SDS-PAGE)
Synonym(s):
Hp 1-1
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.32
Pricing and availability is not currently available.
1 of 4
This Item | SRP6506 | H3536 | H0138 |
|---|---|---|---|
| assay ≥95% (SDS-PAGE) | assay ≥95% (SDS-PAGE) | assay ≥95% (SDS-PAGE) | assay 98-100% |
| biological source human plasma | biological source human plasma | biological source human plasma (pooled) | biological source human |
| form lyophilized | form lyophilized | form lyophilized powder | form essentially salt-free, lyophilized powder |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
| mol wt 86 kDa | mol wt monomer 200 kDa (Hp 2-1), monomer 400 kDa (Hp 2-2), monomer 86 kDa (Hp 1-1) | mol wt - | mol wt - |
| shipped in wet ice | shipped in wet ice | shipped in - | shipped in - |
General description
Haptoglobin is a positive acute-phase plasma α2-sialoglycoprotein, and exists as three major phenotypes namely Hp 1-1, Hp 2-1, and Hp 2-2. Haptoglobin is composed of heavy β- (40 kDa) and light α- (α1= 8.9kDa and α2= 16kDa) chains. Hp 1-1 is the smallest phenotype with a molecular weight of 86kDa, and is composed of only α1.[1][2][3]
Biochem/physiol Actions
Haptoglobin functions as an antioxidant by binding free hemoglobin, and eliminates it from circulation to prevent iron loss and renal injury following hemolysis. It is responsible for maintaining the helper T-cell type 1 and type 2 (Th1/Th2) balance, and functions as an immunosuppressor of lymphocyte function. It also functions as an angiogen and anti-inflammatory agent. Hp 1-1 phenotype is most effective in binding free hemoglobin and preventing inflammatory responses linked with free hemoglobin.[1][2] Studies show that all the three phenotypes of haptoglobin are involved in idiopathic generalized epilepsy.[3]
Physical form
Lyophilized as a salt-free solid.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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