SRP8030

Fn14 (human): FC (human)

recombinant, expressed in HEK 293 cells, >95% (SDS-PAGE)

• Synonym(s): CD266, E1A-associated protein p300, FGF-inducible 14, Tumor necrosis factor receptor superfamily member 12A
• UNSPSC Code: 51111800
• NACRES: NA.32

Properties

• biological source: human
• recombinant: expressed in HEK 293 cells
• assay: >95% (SDS-PAGE)
• form: lyophilized
• mol wt: ~35 kDa by SDS-PAGE
• packaging: pkg of 50 μg
• storage condition: avoid repeated freeze/thaw cycles
• impurities: <0.1 EU/μg endotoxin, tested
• color: white
• UniProt accession no.: Q9NP84
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... TNFRSF12A(51330)

Description

General description

TWEAK is a cytokine that controls proliferation, migration, differentiation, apoptosis, angiogenesis and inflammation. TWEAK binds to Fn14, a highly inducible cell-surface receptor that is linked to several intracellular signalling pathways, including the nuclear factor-B (NF-kappaB) pathway. The TWEAK-Fn14 axis plays a beneficial role in tissue repair following acute injury and may contribute to cancer, chronic autoimmune diseases and acute ischaemic stroke.

Physical form

Lyophilized from PBS.

Preparation Note

Reconstitute with 50 μL deionized water.

Other Notes

The extracellular region of human FN14 (aa 28-75) is fused at the C-terminus to the Fc portion of human IgG1.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable