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MilliporeSigma

SRP8035

Sigma-Aldrich

IL-36α mouse

>95% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized

Synonym(s):

Interleukin-1 family member 6, Interleukin-1 homolog 1, Interleukin-1α, Interleukin-36α

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10 μG
$525.00

About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

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$525.00


Usually ships in 2 weeks.

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Product Name

IL-36α mouse, recombinant, expressed in E. coli, untagged, >95% (SDS-PAGE)

biological source

mouse

recombinant

expressed in E. coli

conjugate

untagged

assay

>95% (SDS-PAGE)

form

lyophilized

mol wt

~17 kDa

packaging

pkg of 10 μg

impurities

<0.01 EU/μg endotoxin, tested

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

mouse ... Il36a(54448)

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This Item
SRP8036SRP8033SRP8032
assay

>95% (SDS-PAGE)

assay

>95% (SDS-PAGE)

assay

>95% (SDS-PAGE)

assay

>95% (SDS-PAGE)

biological source

mouse

biological source

mouse

biological source

mouse

biological source

human

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in HEK 293 cells

form

lyophilized

form

lyophilized

form

lyophilized

form

lyophilized

UniProt accession no.

Q9JLA2

UniProt accession no.

Q9D6Z6

UniProt accession no.

P10749

UniProt accession no.

P14778

impurities

<0.01 EU/μg endotoxin, tested

impurities

<0.01 EU/μg endotoxin, tested

impurities

<0.1 EU/μg endotoxin, tested

impurities

<0.1 EU/μg endotoxin, tested

General description

IL-36α (IL-1F6), IL-36β (IL-1F8) and IL-36γ (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1β, IL-6, TNF-α and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.

Physical form

Lyophilized from PBS.

Reconstitution

Reconstitute with 100 μL deionized water.

Other Notes

IL-36alpha (mouse) (aa 8-160) is untagged.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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