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SRP8037

Sigma-Aldrich

IL-36γ mouse

recombinant, expressed in E. coli, untagged, >95% (SDS-PAGE)

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Synonym(s):
Interleukin-1 family member 9, Interleukin-36γ, SSI-3
NACRES:
NA.32

biological source

mouse

recombinant

expressed in E. coli

conjugate

untagged

Assay

>95% (SDS-PAGE)

form

lyophilized

mol wt

~17 kDa

packaging

pkg of 10 μg

impurities

<0.01 EU/μg endotoxin, tested

color

white

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

mouse ... Il36g(215257)

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SRP8037

IL-36γ mouse

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SRP8035

IL-36α mouse

Sigma-Aldrich

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SRP8036

IL-36β mouse

Sigma-Aldrich

Sigma-Aldrich

SRP6198

IL-36Rα human

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

assay

>95% (SDS-PAGE)

assay

>95% (SDS-PAGE)

assay

>95% (SDS-PAGE)

assay

≥98% (SDS-PAGE)

form

lyophilized

form

lyophilized

form

lyophilized

form

lyophilized powder

mol wt

~17 kDa

mol wt

~17 kDa

mol wt

~17 kDa

mol wt

17 kDa

packaging

pkg of 10 μg

packaging

pkg of 10 μg

packaging

pkg of 10 μg

packaging

pkg of 10 and 50 μg

General description

IL-36α (IL-1F6), IL-36β (IL-1F8) and IL-36γ (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1β, IL-6, TNF-α and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.

Physical form

Lyophilized from PBS and 0.5% trehalose.

Reconstitution

Reconstitute with 100 μL deionized water.

Other Notes

IL-36gamma (mouse) (aa 13-164) is untagged.

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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