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SRP8038

Sigma-Aldrich

IL-38 mouse

recombinant, expressed in E. coli, FLAG® tagged, >95% (SDS-PAGE)

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Synonym(s):
CD223, Interleukin-1 family member 10, Interleukin-38
NACRES:
NA.32

biological source

mouse

recombinant

expressed in E. coli

tag

FLAG® tagged

Assay

>95% (SDS-PAGE)

form

lyophilized

mol wt

~20 kDa

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

<0.01 EU/μg endotoxin, tested

color

white

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

mouse ... Il1f10(215274)

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IL-36β mouse

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in HEK 293 cells

assay

>95% (SDS-PAGE)

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

assay

>95% (SDS-PAGE)

assay

>95% (SDS-PAGE)

form

lyophilized

form

lyophilized

form

lyophilized

form

lyophilized

mol wt

~20 kDa

mol wt

~13.3 kDa

mol wt

~17 kDa

mol wt

~80 kDa by SDS-PAGE

packaging

pkg of 10 μg

packaging

pkg of 10 μg

packaging

pkg of 10 μg

packaging

pkg of 50 μg

General description

IL-38 (IL-1F10) mRNA is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-1F10 in the inflammatory response.

Physical form

Lyophilized from PBS and 0.5% trehalose.

Reconstitution

Reconstitute with 100 μL deionized water.

Other Notes

IL-38 [IL-1F10] (mouse) (aa 3-152) is fused at the C-terminus to a FLAG-tag.

Legal Information

FLAG is a registered trademark of Sigma-Aldrich Co. LLC

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Ina Rudloff et al.
Arthritis & rheumatology (Hoboken, N.J.), 67(12), 3219-3225 (2015-09-01)
Knowledge of interleukin-38 (IL-38), formerly IL-1 family member 10, is sparse, but Il1f10 polymorphisms are associated with inflammatory diseases, and recombinant IL-38 inhibits inflammatory responses similar to those reported in the context of systemic lupus erythematosus (SLE). We undertook this

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