SRP8046

Netrin-1 (human): FC (human)

recombinant, expressed in HEK 293 cells, >95% (SDS-PAGE)

• Synonym(s): ACRP30headless:TNFSF13, NTN1
• UNSPSC Code: 12352200
• NACRES: NA.32

Properties

• biological source: human
• recombinant: expressed in HEK 293 cells
• assay: >95% (SDS-PAGE)
• form: lyophilized
• mol wt: ~90 kDa by SDS-PAGE
• packaging: pkg of 10 μg
• storage condition: avoid repeated freeze/thaw cycles
• impurities: <0.1 EU/μg endotoxin, tested
• color: white
• UniProt accession no.: O95631
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... NTN1(9423)

Description

General description

Netrin-1 controls guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Netrin 1 is also Involved in tumorigenesis by regulating apoptosis.

Physical form

Lyophilized from PBS with trehalose and Brij35.

Preparation Note

Reconstitute with 100 μL deionized water.

Other Notes

Human netrin-1 (aa 25-604) is fused at the C-terminus to the Fc portion of human IgG1.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable