SRP8047

Omentin human

recombinant, expressed in CHO cells, FLAG^® tagged, >95% (SDS-PAGE)

• Synonym(s): ACRP30headless:TNFSF13, Endothelial lectin HL-1, Galactofuranose-binding Lectin, Intestinal lactoferrin receptor, Omentin 1
• CAS Number: 786735-12-4
• NACRES: NA.32
• UNSPSC Code: 12352200
• Form: lyophilized
• Assay: >95% (SDS-PAGE)
• Biological source: human
• Recombinant: expressed in CHO cells
• Mol wt: ~38 kDa

Properties

• Product Name: Omentin human, recombinant, expressed in CHO cells, FLAG^® tagged, >95% (SDS-PAGE)
• biological source: human
• recombinant: expressed in CHO cells
• tag: FLAG^® tagged
• assay: >95% (SDS-PAGE)
• form: lyophilized
• mol wt: ~38 kDa
• packaging: pkg of 10 μg
• storage condition: avoid repeated freeze/thaw cycles
• technique(s): ligand binding assay: suitable
• impurities: <0.1 EU/μg endotoxin, tested
• color: white
• UniProt accession no.: Q8WWA0
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... ITLN1(55600)

Description

Application

Omentin (intelectin-1) has been used in intelectin binding and cleavage assays.[1]

Biochem/physiol Actions

Omentin (intelectin-1) has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes.[2] It increases protein kinase B (AKT) phosphorylation in the absence and presence of insulin. Omentin was suggested to play a role in the defense system against microorganisms by recognizing carbohydrate chains of pathogens and bacterial components containing galactofuranosyl residues.[3] It has anti-inflammatory and insulin-sensitizing properties. The protein may be a biomarker of metabolic disorders.[4] It has been shown to be over-expressed in human malignant pleural mesothelioma (MPM).[3]

General description

Omentin (intelectin-1) is highly expressed in omental adipose tissue, small intestine and various other tissues. It is a plasma adipokine made up of 313 amino acids.[5]

Other Notes

Human omentin (aa 17-313) is fused at the N-terminus to a FLAG^®-tag.

Physical form

Lyophilized from PBS.

Preparation Note

Reconstitute with 100 μL deionized water.

Legal Information

FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable