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SRP8059

Sigma-Aldrich

Jagged-2 (human): FC (human)

recombinant, expressed in HEK 293 cells, ≥90% (SDS-PAGE)

Synonym(s):

Alpha-ketoglutarate-dependent dioxygenase FTO, Protein jagged-2, hJ2

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10 μG
$381.00

About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

$381.00

Usually ships in 2 weeks.
Request a Bulk Order

recombinant

expressed in HEK 293 cells

assay

≥90% (SDS-PAGE)

form

lyophilized

mol wt

~150 kDa by SDS-PAGE

impurities

<0.1 EU/μgtested

UniProt accession no.

Q9Y219

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... JAG2(3714)

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Jagged-2 (human): FC (human) recombinant, expressed in HEK 293 cells, &#8805;90% (SDS-PAGE)

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SRP8052

CD279 (human): FC (human)

recombinant

expressed in HEK 293 cells

recombinant

expressed in HEK 293 cells

recombinant

expressed in HEK 293 cells

recombinant

expressed in CHO cells

assay

≥90% (SDS-PAGE)

assay

>90% (SDS-PAGE)

assay

>90% (SDS-PAGE)

assay

≥98% (SDS-PAGE)

mol wt

~150 kDa by SDS-PAGE

mol wt

~150 kDa by SDS-PAGE

mol wt

~70 kDa by SDS-PAGE

mol wt

monomer 46 kDa by calculation

form

lyophilized

form

liquid

form

liquid

form

lyophilized

impurities

<0.1 EU/μgtested

impurities

<0.1 EU/μg endotoxin, tested

impurities

<0.1 EU/μg endotoxin, tested

impurities

<0.06 EU/μg endotoxin, tested

UniProt accession no.

Q9Y219

UniProt accession no.

P78504

UniProt accession no.

Q6UY11

UniProt accession no.

Q15116

General description

Jagged-2 is a putative Notch ligand involved in the mediation of Notch signaling, that can induce stromal cells to secrete IL-6, VEGF and IGF-1. Notch activation can interact with NF-kappaB and C-myc to promote the proliferation and to inhibit the apoptosis of MM cells, showing in the relationship between the incidence of myeloma and drug resistance. Jagged-2 is also involved in limb development.

Sequence

Human Jagged-2 (aa 1-1054) is fused at the C-terminus to the Fc portion of human IgG.

Physical form

Lyophilized. Contains PBS + 0.02 % CHAPS.

Reconstitution

Reconstitute with 100μl sterile water.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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