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T0307

Sigma-Aldrich

Tyloxapol

BioXtra

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Synonym(s):
4-(1,1,3,3-Tetramethylbutyl)phenol polymer with formaldehyde and oxirane
CAS Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.25

description

non-ionic

Quality Level

product line

BioXtra

impurities

<0.0005% Phosphorus (P)

ign. residue

<1.0%

CMC

0.018 mM

transition temp

cloud point 94.3 °C

anion traces

chloride (Cl-): <0.05%
sulfate (SO42-): <0.6%

cation traces

Al: <0.0005%
Ca: <0.0005%
Cu: <0.0005%
Fe: <0.001%
K: <0.005%
Mg: <0.0005%
NH4+: <0.05%
Na: <0.5%
Pb: <0.001%
Zn: <0.0005%

SMILES string

[H]C([H])=O.OCCO.CC(C)(C)CC(C)(C)c1ccc(O)cc1

InChI

1S/C14H22O.C2H6O2.CH2O/c1-13(2,3)10-14(4,5)11-6-8-12(15)9-7-11;3-1-2-4;1-2/h6-9,15H,10H2,1-5H3;3-4H,1-2H2;1H2

InChI key

GWJOFBXSBDVUMH-UHFFFAOYSA-N

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1 of 4

This Item
T8761X45X114
Tyloxapol BioXtra

T0307

Tyloxapol

Premium Grade
Tyloxapol nonionic surfactant

T8761

Tyloxapol

-
Triton&#8482; X-45

X45

Triton X-45

-
Triton&#8482; X-114 laboratory grade

X114

Triton X-114

-
transition temp

cloud point 94.3 °C

transition temp

cloud point 94.3 °C

transition temp

pour point ~−26 °C

transition temp

pour point ~−9 °C, cloud point 23 °C

description

non-ionic

description

-

description

non-ionic

description

non-ionic

cation traces

Al: <0.0005%, Cu: <0.0005%, K: <0.005%, NH4+: <0.05%, Pb: <0.001%, Ca: <0.0005%, Mg: <0.0005%, Zn: <0.0005%, Fe: <0.001%, Na: <0.5%

cation traces

-

cation traces

-

cation traces

-

product line

BioXtra

product line

-

product line

-

product line

-

impurities

<0.0005% Phosphorus (P)

impurities

-

impurities

-

impurities

-

General description

Tyloxapol is a biocompatible surfactant
A nonionic liquid polymer of the alkyl aryl polyether alcohol type. Used as a surfactant.

Application

Tyloxapol has been used in a study to assess the enhanced pulmonary absorption of recombinant human insulin. It has also been used in a study to investigate the metabolic pathways promoting intrahepatic fatty acid accumulation in methionine and choline deficiency.

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

235.4 °F - closed cup

flash_point_c

113 °C - closed cup

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter


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Martina Theresa Hackl et al.
Nature communications, 10(1), 2717-2717 (2019-06-22)
Hepatic steatosis develops when lipid influx and production exceed the liver's ability to utilize/export triglycerides. Obesity promotes steatosis and is characterized by leptin resistance. A role of leptin in hepatic lipid handling is highlighted by the observation that recombinant leptin
Jianheng Zheng et al.
Die Pharmazie, 67(5), 448-451 (2012-07-07)
Natural pulmonary surfactant (PS) and its artificial substitute phospholipid hexadecanol tyloxapol (PHT) are effective absorption enhancers on promoting recombinant human insulin (Rh-ins) absorption in vivo, but the in vitro efficacy and underlying mechanism remains unclear. In the current study, the
Formulation of Tyloxapol niosomes for encapsulation, stabilization and dissolution of anti-tubercular drugs
Mehta, S. and N. Jindal
Colloids and Surfaces. B, Biointerfaces, 434?441-434?441 (2013)
David P Macfarlane et al.
American journal of physiology. Endocrinology and metabolism, 300(2), E402-E409 (2010-12-02)
The pathological mechanisms that distinguish simple steatosis from steatohepatitis (or NASH, with consequent risk of cirrhosis and hepatocellular cancer) remain incompletely defined. Whereas both a methionine- and choline-deficient diet (MCDD) and a choline-deficient diet (CDD) lead to hepatic triglyceride accumulation
Aki Uchida et al.
Frontiers in physiology, 3, 26-26 (2012-03-01)
Obesity results in abnormally high levels of triglyceride (TG) storage in tissues such as liver, heart, and muscle, which disrupts their normal functions. Recently, we found that lean mice challenged with high levels of dietary fat store TGs in cytoplasmic

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