This product is sourced from rice as stated on the product detail page.
T0452
D-α-Tocotrienol
from rice, ≥75% (GC)
Synonym(s):
3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-2H-1-benzopyran-6-ol
Sign In to View Organizational & Contract Pricing.
About This Item
Empirical Formula (Hill Notation):
C29H44O2
CAS Number:
Molecular Weight:
424.66
UNSPSC Code:
12352205
NACRES:
NA.79
Skip To
SMILES string
O1[C@@](CCc2c1c(c(c(c2C)O)C)C)(CC\C=C(\CC\C=C(\CCC=C(C)C)/C)/C)C
InChI
1S/C29H44O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h12,14,16,30H,9-11,13,15,17-19H2,1-8H3/b21-14+,22-16+/t29-/m1/s1
InChI key
RZFHLOLGZPDCHJ-XZXLULOTSA-N
biological source
rice
assay
≥75% (GC)
form
liquid
color
colorless to brown
mp
30-31 °C
storage temp.
−20°C
Quality Level
1 of 4
This Item | 07205 | 68814 | T0577 |
|---|---|---|---|
| biological source rice | biological source Elaeis guineensis | biological source - | biological source rice |
| assay ≥75% (GC) | assay ≥97.0% (HPLC) | assay ≥97.0% (HPLC) | assay - |
| form liquid | form liquid, viscous liquid | form - | form liquid |
| storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. −20°C |
| color colorless to brown | color colorless to amber | color faint beige to beige, white to yellow | color yellow to orange |
| mp 30-31 °C | mp - | mp - | mp - |
Biochem/physiol Actions
α-Tocotrienol is an effective free radical scavengerand elicits protective functionality during oxidative stress in microsomes.[1] It is a strong antioxidant,[2] which reduces inflammation[3] and is used in cancer treatment.[4] α-tocotrienol supplementation may reduce cholesterol levels in hypercholesterolemia.[4] α-tocotrienol is neuroprotective as it blocks glutamate-induced cell death in neuronal cells.[5]
α-Tocotrienol may be used along with other isoforms to differentiate tocotrienol activities.
Tocotrienols are widely utilized for their strong antioxidant properties. The various isoforms of tocotrienols differ in their methyl substitution in the chromanol head. α-tocotrienol demonstrates neuroprotective properties by blocking glutamate-induced cell death in neuronal cells.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Molecular aspects of alpha-tocotrienol antioxidant action and cell signalling
Packer L, et al.
The Journal of Nutrition, 131(2), 369S-373S (2001)
Vladimir Gogvadze et al.
International journal of cancer, 127(8), 1823-1832 (2010-01-28)
Release of mitochondrial proteins such as cytochrome c, AIF, Smac/Diablo etc., plays a crucial role in apoptosis induction. A redox-silent analog of vitamin E, alpha-tocopheryl succinate (alpha-TOS), was shown to stimulate cytochrome c release via production of reactive oxygen species
Hyunil Ha et al.
Biochemical and biophysical research communications, 406(4), 546-551 (2011-03-01)
Vitamin E, an essential nutrient with powerful antioxidant activity, is the mixture of two classes of compounds, tocopherols (TPs) and tocotrienols (TTs). Although TTs exhibit better bone protective activity than α-TP, the underlying mechanism is poorly understood. In this study
Tocotrienol is a cardioprotective agent against ageing-associated cardiovascular disease and its associated morbidities
Ramanathan N, et al.
Nutrition & Metabolism, 15(1), 6-6 (2018)
Han-A Park et al.
Stroke, 42(8), 2308-2314 (2011-07-02)
α-Tocotrienol (TCT) represents the most potent neuroprotective form of natural vitamin E that is Generally Recognized As Safe certified by the U.S. Food and Drug Administration. This work addresses a novel molecular mechanism by which α-TCT may be protective against
-
what is the source of Tocotrienol rice or rice bran oil
1 answer-
Helpful?
-
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service