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T0576

Sigma-Aldrich

Tau-441 human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE), lyophilized powder

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MDL number:
NACRES:
NA.32

biological source

human

Quality Level

recombinant

expressed in E. coli

assay

≥90% (SDS-PAGE)

form

lyophilized powder

mol wt

45.9 kDa

UniProt accession no.

application(s)

cell analysis

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... MAPT(4137)

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This Item
T0326SAE0076T0451
Sigma-Aldrich

T0576

Tau-441 human

Sigma-Aldrich

T0326

Tau-412 human

Tau-441 human recombinant, lyophilized powder, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

SAE0076

Tau-441 human

Sigma-Aldrich

T0451

Tau-410 human

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in HEK 293 cells

recombinant

expressed in E. coli

biological source

human

biological source

human

biological source

human

biological source

human

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

mol wt

45.9 kDa

mol wt

42.9 kDa

mol wt

calculated mol wt 50.3 kDa (including c-terminal His and V5 tags), observed mol wt 70-100 kDa by SDS-PAGE (The protein migrates as a 70-110 kDa protein on SDS-PAGE due to glycosylation)

mol wt

42.6 kDa

Gene Information

human ... MAPT(4137)

Gene Information

human ... MAPT(4137)

Gene Information

human ... MAPT(4137)

Gene Information

human ... MAPT(4137)

General description

Tau-441 human, recombinant, is an isoform of Tau, variant 2N4R, having 4 microtubule binding repeats (R) and 2 amino terminal inserts (N). Tau is a family of neuronal microtubule-associated proteins. Tau, a phosphoprotein is considered as an important microtubule associated protein (MAP) of a mature neuron. The 2N4R tau consists of 441 amino acids (tau441) and is considered as the largest size human brain tau. In human brain, tau is present in six molecular isoforms.
The gene microtubule associated protein tau (MAPT) is localized on human chromosome 17q21.3. It is expressed in neurons, more specifically in axons.

Application

Human Tau-441 has been used to study the effects of tau on neuropathological changes in Alzheimer′s disease.
Tau-441 human has been used to study its effects on mitochondrial transport velocities found in glial cells.

Biochem/physiol Actions

Microtubule associated protein tau (MAPT) plays an important role in the assembly and maintenance of the microtubule structure. Loss of expression of MAPT results in developmental delay and learning disability. The protein has been associated with pathology of Alzheimer′s disease (AD).
Tau promotes assembly and stabilizes neuronal microtubules under normal physiological conditions.
Isoform of Tau, variant 2N4R, having 4 microtubule binding repeats (R) and 2 amino terminal inserts (N)

Reconstitution

Lyophilized from MES, pH 6.8, containing NaCl and EGTA. When reconstituted in water to a protein concentration of 1 mg/mL, the resulting buffer will have ~50 mM MES, pH 6.8, 100 mM NaCl, and 0.5 mM EGTA.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Customers Also Viewed

Slide 1 of 7

1 of 7

The H1c haplotype at the MAPT locus is associated with Alzheimer's disease
A. J. Myers
Human Molecular Genetics, 14 (2005)
Microdeletion encompassing MAPT at chromosome 17q21. 3 is associated with developmental delay and learning disability
Shaw-Smith, Charles, et al
Nature Genetics, 38 (2006)
Tau in Alzheimer Disease and Related Tauopathies
Iqbal K, et al.
Current Alzheimer Research, 7(8), 656-656 (2010)
Seed-competent HMW tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients
Shuko Takeda
Annals of Neurology (2016)
Preliminary study of effect of exogenous tau-441 on mitochondrial transport in glia.
Morgan MX
wheaton journal of neurobiology research (2017)

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