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T0875

Sigma-Aldrich

Sodium taurodeoxycholate hydrate

≥95% (HPLC)

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Synonym(s):
2-([3α,12α-Dihydroxy-24-oxo-5β-cholan-24-yl]amino)ethanesulfonic acid, Taurodeoxycholic acid sodium salt hydrate
Linear Formula:
C26H44NO6SNa · xH2O
CAS Number:
Molecular Weight:
521.69 (anhydrous basis)
Beilstein/REAXYS Number:
3901204
MDL number:
PubChem Substance ID:
NACRES:
NA.25

description

anionic

Quality Level

assay

≥95% (HPLC)

mol wt

micellar avg mol wt 3100

aggregation number

6

CMC

1-4 mM (20-25°C)

application(s)

sample preservation

SMILES string

O.[Na+].C[C@H](CCC(=O)NCCS([O-])(=O)=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C

InChI

1S/C26H45NO6S.Na.H2O/c1-16(4-9-24(30)27-12-13-34(31,32)33)20-7-8-21-19-6-5-17-14-18(28)10-11-25(17,2)22(19)15-23(29)26(20,21)3;;/h16-23,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33);;1H2/q;+1;/p-1/t16-,17-,18-,19+,20-,21+,22+,23+,25+,26-;;/m1../s1

InChI key

OLPIZAYYAVQETM-GGPRKOIFSA-M

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Show Differences

1 of 4

This Item
T0557T9034T4009
vibrant-m

T0875

Sodium taurodeoxycholate hydrate

-
vibrant-m

T0557

Sodium taurodeoxycholate hydrate

Premium Grade
vibrant-m

T9034

Taurocholic acid sodium salt hydrate

Premium Grade
vibrant-m

T4009

Taurocholic acid sodium salt hydrate

-
aggregation number

6

aggregation number

6

aggregation number

4

aggregation number

4

application(s)

sample preservation

application(s)

-

application(s)

detection

application(s)

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

CMC

1-4 mM (20-25°C)

CMC

1-4 mM (20-25°C)

CMC

3-11 mM (20-25°C)

CMC

3-11 mM (20-25°C)

mol wt

micellar avg mol wt 3100

mol wt

micellar avg mol wt 3100

mol wt

micellar avg mol wt 2100

mol wt

micellar avg mol wt 2100

Application

Sodium taurodeoxycholate hydrate has been used in a study to assess the effect of submicellar concentrations of bile salts on the lipid bilayer membrane. It has also been used in a study to investigate polymorphic behavior in protein-surfactant mixtures.
Bile salt-related, anionic detergent used for isolation of membrane proteins including inner mitochondrial membrane proteins.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Barbara Orioni et al.
The journal of physical chemistry. B, 110(24), 12129-12140 (2006-06-28)
Mixtures containing water, bovine serum albumin (BSA), and sodium taurodeoxycholate (NaTDC), a component of the bile in mammals, have been investigated in a wide range of composition and pH. Depending on the concentration of both solutes and the pH, solutions
Jing-Yi Ye et al.
International journal of nanomedicine, 15, 6503-6518 (2020-09-15)
A non-lipolysis nanoemulsion (NNE) was designed to reduce the first-pass metabolism of raloxifene (RAL) by intestinal UDP-glucuronosyltransferases (UGTs) for increasing the oral absorption of RAL, coupled with in vitro and in vivo studies. In vitro stability of NNE was evaluated
Nitya Subrahmanian et al.
Genetics, 214(4), 895-911 (2020-02-23)
Complex I is the first enzyme involved in the mitochondrial electron transport chain. With >40 subunits of dual genetic origin, the biogenesis of complex I is highly intricate and poorly understood. We used Chlamydomonas reinhardtii as a model system to
Monalisa Mohapatra et al.
Langmuir : the ACS journal of surfaces and colloids, 27(22), 13461-13467 (2011-10-07)
The interaction of submicellar concentrations of various physiologically important unconjugated [sodium deoxycholate (NaDC), sodium cholate (NaC)] and conjugated [sodium glycodeoxycholate (NaGDC), sodium glycocholate (NaGC), sodium taurodeoxycholate (NaTDC), sodium taurocholate (NaTC)] bile salts with dipalmitoylphosphatidylcholine (DPPC) and dimyristoylphosphatidylcholine (DMPC) small unilamellar
Xiao-Feng Zhang et al.
Food chemistry, 274, 305-313 (2018-10-31)
The low expression level of acidic lipases from Aspergillus sp. remains a major obstacle for their use in industrial applications. In this study, fusion expression with three fusion partners was investigated to enhance the expression level of an acidic lipase

Protocols

This method is particularly useful in research into the role of individual bile acids as signaling molecules; suitable for clinical laboratories to investigate potential mechanisms linked to gut hormone profiles and glycemic control.

Related Content

Bile Acids (BA) are synthesized in the liver and play important roles in cholesterol homeostasis, absorption of vitamins and lipids, and various key metabolic processes.

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