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T1001

Sigma-Aldrich

Thyroglobulin from bovine thyroid

powder, ≥90% (agarose gel electrophoresis)

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Synonym(s):
Globulins thyro, Thyractin
CAS Number:
EC Number:
MDL number:
NACRES:
NA.61

biological source

bovine thyroid

Assay

≥90% (agarose gel electrophoresis)

form

powder

mol wt

~670 kDa

composition

Iodine, ≥0.20%

nitrogen analysis

13.0-16.0% total

ash

≤4%

solubility

H2O: 20 mg/mL

UniProt accession no.

storage temp.

−20°C

Gene Information

cow ... TG(280706)

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This Item
T9145A3983A2058
Bovine Serum Albumin lyophilized powder, essentially γ-globulin free, ≥98% (agarose gel electrophoresis)

Sigma-Aldrich

A3983

Bovine Serum Albumin

Bovine Serum Albumin lyophilized powder, essentially IgG-free, low endotoxin, BioReagent, suitable for cell culture

Sigma-Aldrich

A2058

Bovine Serum Albumin

assay

≥90% (agarose gel electrophoresis)

assay

-

assay

≥98% (agarose gel electrophoresis)

assay

≥95% (agarose gel electrophoresis)

form

powder

form

powder

form

lyophilized powder

form

lyophilized powder

mol wt

~670 kDa

mol wt

~670 kDa

mol wt

~66 kDa

mol wt

~66 kDa

solubility

H2O: 20 mg/mL

solubility

-

solubility

water: soluble, clear to slightly hazy (1 g + 25 mL)

solubility

water: soluble (40 mg/ml)

UniProt accession no.

P01267

UniProt accession no.

P01267

UniProt accession no.

P02769

UniProt accession no.

P02769

Application

Bovine thyroglobulin was shown to stimulate proliferation in rat thyroid follicular cells as well as in primary porcine thyroid epithelial cells. This effect was mediated through PI3K signaling.
Often used as a carrier protein for the production of antibodies. Its advantage is the large number of tyrosine residues that can be used for conjugation using the diazo reaction.

Biochem/physiol Actions

Bovine thyroglobulin is a large, tetrameric glycoprotein produced in the thyroid gland as a precursor to thyroid hormones. Its large size and absence from plasma under normal conditions makes it very immunogenic and reduces the chance that antibodies to this carrier protein will cross-react with plasma proteins in immunoassays. Haptens may be conjugated to thyroglobulin via accessible secondary amines.
Iodine-containing protein that is stored in the thyroid gland. Converted into circulating thyroxines when the thyroid is stimulated by thyroid-stimulating hormone (TSH) from the pituitary. Because its expression is unique to the thyroid, it is a sensitive indicator of recurrence or metastasis of thyroid cancer that has been treated by thyroid ablation.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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