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T1428

Sigma-Aldrich

apo-Transferrin bovine

BioReagent, suitable for cell culture, ≥98%

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Synonym(s):
Human serotransferrin
CAS Number:
EC Number:
MDL number:
NACRES:
NA.83

biological source

bovine

Quality Level

product line

BioReagent

assay

≥98%

form

powder

technique(s)

cell culture | mammalian: suitable

impurities

iron, essentially free

solubility

H2O: 10 mg/mL

UniProt accession no.

storage temp.

2-8°C

Gene Information

bovine ... TF(280705)

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1 of 4

This Item
T0178T2036T4382
vibrant-m

T1428

apo-Transferrin bovine

vibrant-m

T0178

apo-Transferrin bovine

vibrant-m

T2036

apo-Transferrin human

vibrant-m

T4382

apo-Transferrin human

biological source

bovine

biological source

bovine

biological source

-

biological source

human

assay

≥98%

assay

≥98%

assay

≥98% (agarose gel electrophoresis)

assay

≥98% (agarose gel electrophoresis)

solubility

H2O: 10 mg/mL

solubility

H2O: 20 mg/mL

solubility

H2O: 50 mg/mL

solubility

H2O: 50 mg/mL

Gene Information

bovine ... TF(280705)

Gene Information

bovine ... TF(280705)

Gene Information

human ... TF(7018)

Gene Information

human ... TF(7018)

form

powder

form

powder

form

powder

form

powder

General description

apo-Transferrin is an iron-free form of transferrin that is present in circulation.

Application

All cells require iron for the proper uptake of oxygen from their environment. Transferrin, a protein isolated from serum, causes the uptake and transport of iron from culture medium to the cells. This allows proper oxygen uptake and also stimulates growth-related enzyme activity. Iron-saturated transferrin (holo transferrin) is continually recycled after releasing iron and becomes iron-deficient transferrin (apo-transferrin). Choosing which form to use depends upon the culture conditions. In media such as Dulbecco′s Modified Eagle′s Medium/Ham′s Nutrient Mixture F12 (DMEM/F12) that contain high levels of iron salt, using apo-transferrin is preferred.
apo-Transferrin bovine has been used as a component of:
  • basal medium for culturing bovine mammary epithelial cells
  • minimum essential medium α (MEM-α) for spermatogonial stem cells (SSCs) culture
  • induction medium for mesenchymal stem cell culture

Biochem/physiol Actions

apo-Transferrin (apoTf) aids in preventing iron accumulation in tissues, especially in non-transfusion dependent β-thalassemia.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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The objective of this study was to study how changing the ratio of Lys to Thr, Lys to His, and Lys to Val affects the expression of lipogenic genes and microRNA (miRNA) in bovine mammary epithelial cells. Triplicate cultures with
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Intermediate beta-thalassemia has a broad spectrum of sequelae and affected subjects may require occasional blood transfusions over their lifetime to correct anemia. Iron overload in intermediate beta-thalassemia results from a paradoxical intestinal absorption, iron release from macrophages and hepatocytes, and
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We have investigated the mechanism of manganese ion uptake by apo-transferrin using a capillary electrophoresis method, and obtained clear evidence that oxidation state +3 and the binuclear unit of a manganese chelate are essential factors for the facile uptake by

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