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MilliporeSigma

T1428

apo-Transferrin bovine

BioReagent, suitable for cell culture, ≥98%

Synonym(s):

Human serotransferrin

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About This Item

CAS Number:
11096-37-0
UNSPSC Code:
12352202
EC Number:
234-318-8
NACRES:
NA.83
MDL number:
MFCD00130536
eCl@ss:
34058011
Form:
powder
Assay:
≥98%
Biological source:
bovine

Key Documents

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biological source

bovine

product line

BioReagent

assay

≥98%

form

powder

technique(s)

cell culture | mammalian: suitable

impurities

iron, essentially free

solubility

H2O: 10 mg/mL

UniProt accession no.

Q29443

storage temp.

2-8°C

Quality Level

200

Gene Information

bovine ... TF(280705)

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This Item
T1283T2252178481
apo-Transferrin bovine BioReagent, suitable for cell culture, ≥98%

Sigma-Aldrich

T1428

apo-Transferrin bovine

holo-Transferrin bovine Iron-saturated, BioReagent, suitable for cell culture

Sigma-Aldrich

T1283

holo-Transferrin bovine

apo-Transferrin human ≥95% protein basis (biuret)

Sigma-Aldrich

T2252

apo-Transferrin human

Transferrin, Apo-, Low Endotoxin Grade, Human Plasma

Sigma-Aldrich

178481

Transferrin, Apo-, Low Endotoxin Grade, Human Plasma

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

-

biological source

bovine

biological source

-

biological source

human

biological source

-

assay

≥98%

assay

97-100% (agarose gel electrophoresis)

assay

≥95% protein basis (biuret), ≥98% (agarose gel electrophoresis)

assay

≥95% (SDS-PAGE)

form

powder

form

powder

form

powder

form

lyophilized solid

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

UniProt accession no.

Q29443

UniProt accession no.

Q29443

UniProt accession no.

P02787

UniProt accession no.

-

General description

apo-Transferrin is an iron-free form of transferrin that is present in circulation.[1]

Application

All cells require iron for the proper uptake of oxygen from their environment. Transferrin, a protein isolated from serum, causes the uptake and transport of iron from culture medium to the cells. This allows proper oxygen uptake and also stimulates growth-related enzyme activity. Iron-saturated transferrin (holo transferrin) is continually recycled after releasing iron and becomes iron-deficient transferrin (apo-transferrin). Choosing which form to use depends upon the culture conditions. In media such as Dulbecco′s Modified Eagle′s Medium/Ham′s Nutrient Mixture F12 (DMEM/F12) that contain high levels of iron salt, using apo-transferrin is preferred.
apo-Transferrin bovine has been used as a component of:
  • basal medium for culturing bovine mammary epithelial cells[2][3]
  • minimum essential medium α (MEM-α) for spermatogonial stem cells (SSCs) culture[4]
  • induction medium for mesenchymal stem cell culture[5]

Biochem/physiol Actions

apo-Transferrin (apoTf) aids in preventing iron accumulation in tissues, especially in non-transfusion dependent β-thalassemia.[6]

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000453132
0000453132
0000365736
0000365735
0000365736

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Function and therapeutic development of apotransferrin.
Jaakko Parkkinen et al.
Vox sanguinis, 83 Suppl 1, 321-326 (2003-03-06)
Jia Wang et al.
Stem cell research & therapy, 10(1), 227-227 (2019-07-31)
High temperature has a very adverse effect on mammalian spermatogenesis and eventually leads to sub- or infertility through either apoptosis or DNA damage. However, the direct effects of heat stress on the development of spermatogonial stem cells (SSCs) are still
Shanshan Li et al.
Journal of animal science and biotechnology, 7, 44-44 (2016-08-06)
The objective of this study was to study how changing the ratio of Lys to Thr, Lys to His, and Lys to Val affects the expression of lipogenic genes and microRNA (miRNA) in bovine mammary epithelial cells. Triplicate cultures with
Keita Abe et al.
Zeitschrift fur Naturforschung. C, Journal of biosciences, 63(1-2), 154-156 (2008-04-05)
We have investigated the mechanism of manganese ion uptake by apo-transferrin using a capillary electrophoresis method, and obtained clear evidence that oxidation state +3 and the binuclear unit of a manganese chelate are essential factors for the facile uptake by
Einar Vargas-Bello-Pérez et al.
Animal nutrition (Zhongguo xu mu shou yi xue hui), 5(2), 202-208 (2019-06-14)
The objective of this study was to determine how cytosolic triacylglycerols (TAG) are stored in mammary cells and whether this depends on the individual chemical configuration of fatty acids (FA). This objective was accomplished by addition of different FA to
View All Related Papers

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