T1698

Sigma-Aldrich

Tetradecylthioacetic acid

≥97% (NMR)

Synonym(s):
TTA
Linear Formula:
C14H29-S-CH2COOH
CAS Number:
Molecular Weight:
288.49
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥97% (NMR)

color

white

solubility

DMSO: soluble ≥22 mg/mL

SMILES string

CCCCCCCCCCCCCCSCC(O)=O

InChI

1S/C16H32O2S/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-19-15-16(17)18/h2-15H2,1H3,(H,17,18)

InChI key

IPBCWPPBAWQYOO-UHFFFAOYSA-N

Gene Information

human ... PPARA(5465)

Packaging

5 mg in glass bottle
Packaged under nitrogen.

Biochem/physiol Actions

Tetradecylthioacetic acid (TTA) is known to modulate lipid homeostasis. TTA can increase fatty acid oxidation and ketogenesis, which can subsequently prevent adiposity and insulin resistance. Furthermore, TTA can enhance cardiac functions during experimental heart failure.
PPARα agonist; activation in ranking order: PPARδ > PPARα > PPARγ

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Preparation Note

Tetradecylthioacetic acid is soluble in DMSO at a concentration that is greater than or equal to 22 mg/ml.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Lise Madsen et al.
Journal of lipid research, 43(5), 742-750 (2002-04-25)
Tetradecylthioacetic acid (TTA) is a non-beta-oxidizable fatty acid analog, which potently regulates lipid homeostasis. Here we evaluate the ability of TTA to prevent diet-induced and genetically determined adiposity and insulin resistance. In Wistar rats fed a high fat diet, TTA...
Erik Øie et al.
Lipids, 48(2), 139-154 (2012-12-26)
Changes in myocardial metabolism, including a shift from fatty acid to glucose utilization and changes in fatty acid availability and composition are characteristics of heart failure development. Tetradecylthioacetic acid (TTA) is a fatty acid analogue lacking the ability to undergo...

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