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T1775

Sigma-Aldrich

L-Thyroxine

powder, BioReagent, suitable for cell culture

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Synonym(s):
3,3′,5,5″-Tetraiodo-L-thyronine, 3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine, T4
Linear Formula:
HOC6H2(I)2OC6H2(I)2CH2CH(NH2)CO2H
CAS Number:
Molecular Weight:
776.87
Beilstein/REAXYS Number:
2228515
EC Number:
MDL number:
eCl@ss:
32190102
PubChem Substance ID:
NACRES:
NA.77

biological source

synthetic

Quality Level

product line

BioReagent

assay

≥98% (HPLC)

form

powder

potency

5-50 ng/mL

technique(s)

cell culture | mammalian: suitable

mp

223 °C (dec.) (lit.)

solubility

4 M NH4OH in methanol: 50 mg/mL, clear to hazy, yellow

shipped in

ambient

storage temp.

room temp

SMILES string

N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O

InChI

1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1

InChI key

XUIIKFGFIJCVMT-LBPRGKRZSA-N

Gene Information

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1 of 4

This Item
PHR1613T2376T5905
vibrant-m

T1775

L-Thyroxine

vibrant-m

PHR1613

Levothyroxine

vibrant-m

T2376

L-Thyroxine

vibrant-m

T5905

L-Thyronine

assay

≥98% (HPLC)

assay

-

assay

≥98% (HPLC)

assay

≥98.0% (TLC)

product line

BioReagent

product line

-

product line

-

product line

-

Quality Level

200

Quality Level

300

Quality Level

200

Quality Level

200

technique(s)

cell culture | mammalian: suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

-

shipped in

ambient

shipped in

-

shipped in

ambient

shipped in

-

General description

Thyroxine (T4) is a tetraiodo derivative of the p-hydroxyphenyl ether of tyrosine, which functions as growth factors or cell growth inhibitors. T4 is used to treat hypothyroidism and thyroid carcinoma. It regulates energy metabolism.

Application

L-Thyroxine has been used to investigate its role in colorectal cancer cell lines HCT 116 (APC wild type) and HT-29 (APC mutant). It has also been used to evaluate its effects on pro-inflammatory tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), angiogenic vascular endothelial growth factor (VEGF), leukocyte adhesion, intercellular adhesion molecule 1 (ICAM-1) and E-selectin in human umbilical vein endothelial cells (HUVECs).

Biochem/physiol Actions

L-Thyroxine (T4) and triiodo-L-thyronine (T3) are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and, thus, protein synthesis.

Preparation Note

For long term storage, keep stock solutions at -20° in working aliquots and avoid repeated freeze/thaw cycles. Solutions stored at 2-8 °C are stable for up to 30 days.

Reconstitution

To prepare 20 μg/ml stock solution, dissolve in 50 ml sterile culture medium per mg thyroxine.

pictograms

Health hazard

signalword

Danger

hcodes

Hazard Classifications

STOT RE 1

Storage Class

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Customers Also Viewed

Slide 1 of 4

1 of 4

Thyroid hormone promotes beta-catenin activation and cell proliferation in colorectal cancer
Lee YS, et al.
Hormones & Cancer, 9(3), 156-165 (2018)
Effects of thyroid-stimulating hormone on adhesion molecules and pro-inflammatory cytokines secretion in human umbilical vein endothelial cells
Milani AT, et al.
Research in Pharmaceutical Sciences, 13(6), 546-546 (2018)
The
Clinical Chemistry, 331(3), 174-180 (2008)
Chemistry of thyroxine. III. Constitution and synthesis of thyroxine
Harrington CR and Barger G
The Biochemical Journal, 21(6), 169-183 (1927)
Thyroxine therapy
Toft AD
The New England Journal of Medicine, 331(3), 174-180 (1994)

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