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T2205

Sigma-Aldrich

TRKC (507-end), active, His tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

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Synonym(s):
NTRK3, gp145(trkC)
NACRES:
NA.32

recombinant

expressed in baculovirus infected Sf9 cells

Quality Level

product line

PRECISIO® Kinase

Assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

20-28 nmol/min·mg

mol wt

~38 kDa

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... NTRK3(4916)

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This Item
T2080SAB1410849SAB1402294
assay

≥70% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

assay

-

assay

-

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

form

buffered aqueous solution

form

buffered aqueous solution

specific activity

20-28 nmol/min·mg

specific activity

63-85 nmol/min·mg

specific activity

-

specific activity

-

mol wt

~38 kDa

mol wt

~67 kDa

mol wt

antigen 68.5 kDa

mol wt

antigen ~39.2 kDa

UniProt accession no.

Q16288

UniProt accession no.

Q16620

UniProt accession no.

Q16288

UniProt accession no.

Q16288

Biochem/physiol Actions

TRKC is a member of the TRK family of tyrosine kinase receptors and is the high affinity catalytic receptor for the neurotrophin NT-3 (neurotrophin-3). TRKC mediates the multiple cellular effects of the NT-3 neurotrophic factor, which includes neuronal differentiation and survival. TRKC has been implicated in insulin signaling pathway through interactions with the MUSK protein receptor and the VEGF receptor. Mutations in the TRKC gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers.

Physical form

Supplied in 50 mM sodium phosphate, pH 7.0, with 150 mM imidazole, 0.1 mM PMSF, 2 mM DTT, and 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Exclamation markHealth hazard

Signal Word

Danger

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1


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Antonio Marchetti et al.
Human mutation, 29(5), 609-616 (2008-02-23)
The neurotrophic tyrosine receptor kinase (NTRK) family is potentially implicated in tumorigenesis and progression of several neoplastic diseases, including lung cancer. We investigated a large number of pulmonary neuroendocrine tumors (PNETs) and non-small cell lung carcinomas (NSCLCs) without morphological evidence
F Lamballe et al.
Cell, 66(5), 967-979 (1991-09-06)
We report the isolation and molecular characterization of trkC, a new member of the trk family of tyrosine protein kinase genes. trkC is preferentially expressed in the brain. In situ hybridization studies revealed trkC transcripts in the hippocampus, cerebral cortex

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