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T2265

Tetraethylammonium chloride

synthetic (organic), ≥98% (titration), K+ channels blocker, powder

Synonym(s):

TEA chloride

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About This Item

Linear Formula:
(C2H5)4N(Cl)
CAS Number:
56-34-8
Molecular Weight:
165.70
NACRES:
NA.32
PubChem Substance ID:
24277874
UNSPSC Code:
12352107
EC Number:
200-267-5
MDL number:
MFCD00011828
Beilstein/REAXYS Number:
3563247
Form:
powder
Assay:
≥98% (titration)
Biological source:
synthetic (organic)

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Product Name

Tetraethylammonium chloride, ≥98% (titration)

InChI key

YMBCJWGVCUEGHA-UHFFFAOYSA-M

InChI

1S/C8H20N.ClH/c1-5-9(6-2,7-3)8-4;/h5-8H2,1-4H3;1H/q+1;/p-1

SMILES string

[Cl-].CC[N+](CC)(CC)CC

biological source

synthetic (organic)

assay

≥98% (titration)

form

powder

technique(s)

blocking: suitable

color

white to light yellow

Quality Level

200

Gene Information

human ... CHRNA1(1134), CHRNA10(57053), CHRNA2(1135), CHRNA3(1136), CHRNA4(1137), CHRNA5(1138), CHRNA6(8973), CHRNA7(1139), CHRNA9(55584), CHRNB1(1140), CHRNB2(1141), CHRNB3(1142), CHRNB4(1143)

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1 of 4

This Item
SAB1402724SAB2108456M217
Tetraethylammonium chloride ≥98% (titration)

Sigma-Aldrich

T2265

Tetraethylammonium chloride

Monoclonal Anti-CHRNA1 antibody produced in mouse clone 2G5, purified immunoglobulin, buffered aqueous solution

Sigma-Aldrich

SAB1402724

Monoclonal Anti-CHRNA1 antibody produced in mouse

Anti-CHRNA7 IgG fraction of antiserum

Sigma-Aldrich

SAB2108456

Anti-CHRNA7

Monoclonal Anti-Nicotinic Acetylcholine Receptor (α1, α3, α5 Subunits) antibody produced in rat clone mAb 35, purified immunoglobulin, buffered aqueous solution

Sigma-Aldrich

M217

Monoclonal Anti-Nicotinic Acetylcholine Receptor (α1, α3, α5 Subunits) antibody produced in rat

technique(s)

blocking: suitable

technique(s)

indirect ELISA: suitable

technique(s)

immunoblotting: suitable

technique(s)

immunohistochemistry (frozen sections): 1:3,000

biological source

synthetic (organic)

biological source

mouse

biological source

rabbit

biological source

rat

assay

≥98% (titration)

assay

-

assay

-

assay

-

form

powder

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

Gene Information

human ... CHRNA1(1134), CHRNA10(57053), CHRNA2(1135), CHRNA3(1136), CHRNA4(1137), CHRNA5(1138), CHRNA6(8973), CHRNA7(1139), CHRNA9(55584), CHRNB1(1140), CHRNB2(1141), CHRNB3(1142), CHRNB4(1143)

Gene Information

human ... CHRNA1(1134)

Gene Information

human ... CHRNA7(1139)

Gene Information

human ... CHRNA1(1134), CHRNA3(1136), CHRNA5(1138)

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

100

Application

Tetraethylammonium chloride (TEAC) has been used:
  • used for inhibition of peroxynitrite induced relaxation in rat aorta rings
  • as a pharmacological blocker of K+ current and Ca2+ induced K+ current in antennal lobe neurons
  • for the induction of TEAC sensitive currents in cochlear inner hair cells digested with proteolytic enzymes and analyze its properties

Biochem/physiol Actions

Blocks K+ channels; blocks nicotinic acetylcholine neurotransmission by blocking the receptor-mediated K+ currents.
Tetraethylammonium chloride (TEAC) blocks K+ channels non-specifically. In rat aorta rings, tetraethylammonium inhibits relaxation induced by peroxynitrite. It blocks nicotinic acetylcholine neurotransmission by blocking the receptor-mediated K+ currents. TEAC can increase the contractility and mobility of colon and rectum and is a therapeutic option for Hirschsprung′s disease patients. TEAC reduces the inflammatory responses, improves cardiac, vascular and hemodynamic properties during early sepsis in animals. TEAC has cytotoxic and anti-proliferative potential and induces apoptosis in glioma cells by downregulating B-cell lymphoma-2 (Bcl-2) and upregulating Bcl-2 associated X (Bax).

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Disclaimer

moisture sensitive, handle under argon

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

201.2 °F - closed cup

flash_point_c

94 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCL6355
BCCF3812
BCBW7641
BCBP1249
BCBP1249V

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Early potassium channel blockade improves sepsis-induced organ damage and cardiovascular dysfunction
Sordi R, et al.
British Journal of Pharmacology, 163(6), 1289-1301 (2011)
Dissociation enzyme effects on the potassium currents of inner hair cells isolated from guinea-pig cochlea
Kimitsuki T, et al.
Hearing Research, 199(1-2), 135-139 (2005)
Tetraethylammonium enhances the rectal and colonic motility in rats and human in vitro
Li Z, et al.
Naunyn-Schmiedeberg'S Archives of Pharmacology, 384(2), 147-155 (2011)
Tetraethylammonium inhibits glioma cells via increasing production of intracellular reactive oxygen species
Yang KB, et al.
Chemotherapy, 55(5), 372-380 (2009)
Differences of Ca2+ handling properties in identified central olfactory neurons of the antennal lobe
Pippow A, et al.
Cell Calcium, 46(2), 87-98 (2009)
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