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  • T3434
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T3434

Sigma-Aldrich

Tyrphostin AG 490

solid

All Photos(1)
Synonym(s):
2-Cyano-3-(3,4-dihydroxyphenyl)-N-(benzyl)-2-propenamide, 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide
Empirical Formula (Hill Notation):
C17H14N2O3
CAS Number:
133550-30-8
Molecular Weight:
294.30
MDL number:
MFCD00236452
PubChem Substance ID:
24278732
NACRES:
NA.77

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658411

InSolution AG490 - Calbiochem

AG 490 - CAS 133550-30-8 - Calbiochem A cell-permeable, reversible, substrate competitive, and potent inhibitor of epidermal growth factor receptor kinase autophosphorylation (IC₅₀ = 100 nM).

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658401

AG 490 - CAS 133550-30-8 - Calbiochem

A cell-permeable, reversible, substrate competitive, and potent inhibitor of epidermal growth factor receptor kinase autophosphorylation (IC₅₀ = 100 nM).

STAT3 Inhibitor III, WP1066 STAT3 Inhibitor III, WP1066, CAS 857064-38-1, is a cell-permeable AG490 tyrphostin analog that acts as a STAT3 pathway inhibitor. A potent anti-tumor agent.

Sigma-Aldrich

573097

STAT3 Inhibitor III, WP1066

STAT3 Inhibitor III, WP1066, CAS 857064-38-1, is a cell-permeable AG490 tyrphostin analog that acts as a STAT3 pathway inhibitor. A potent anti-tumor agent.

Stattic ≥98% (HPLC), powder

Sigma-Aldrich

S7947

Stattic

≥98% (HPLC), powder

JAK Inhibitor I - CAS 457081-03-7 - Calbiochem JAK Inhibitor I, CAS 457081-03-7, is a potent, reversible, cell-permeable, and ATP-competitive inhibitor of JAK 1 (IC₅₀ = 15 nM), JAK2 (IC₅₀ = 1 nM), JAK3 (Ki = 5 nM) and Tyk2 (IC₅₀ = 1 nM).

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420099

JAK Inhibitor I - CAS 457081-03-7 - Calbiochem

JAK Inhibitor I, CAS 457081-03-7, is a potent, reversible, cell-permeable, and ATP-competitive inhibitor of JAK 1 (IC₅₀ = 15 nM), JAK2 (IC₅₀ = 1 nM), JAK3 (Ki = 5 nM) and Tyk2 (IC₅₀ = 1 nM).

Cucurbitacin B hydrate ≥97% (HPLC)

Sigma-Aldrich

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Cucurbitacin B hydrate

≥97% (HPLC)

Tofacitinib citrate ≥98% (HPLC)

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Tofacitinib citrate

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Cucurbitacin I hydrate ≥95% (HPLC), solid

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Cucurbitacin I hydrate

≥95% (HPLC), solid

STAT3 Inhibitor V, Stattic - CAS 19983-44-9 - Calbiochem STAT3 Inhibitor V, Stattic, CAS 19983-44-9, is a cell-permeable inhibitor of STAT3 cellular function that targets the STAT3-SH2 domain and prevents its association with upstream Kinases.

Sigma-Aldrich

573099

STAT3 Inhibitor V, Stattic - CAS 19983-44-9 - Calbiochem

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Niclosamide

Sigma-Aldrich

N3510

Niclosamide

biological source

synthetic (organic)

Quality Level

200

assay

≥98% (HPLC)

form

solid

color

yellow

solubility

DMSO: soluble 10 mg/ml, clear, yellow
ethanol: 5 mg/mL
H2O: insoluble

storage temp.

−20°C

SMILES string

Oc1ccc(cc1O)\C=C(/C#N)C(=O)NCc2ccccc2

InChI

1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+

InChI key

TUCIOBMMDDOEMM-RIYZIHGNSA-N

Gene Information

human ... EGFR(1956) , ERBB2(2064) , IL2(3558) , JAK2(3717)

Application

Tyrphostin AG has been used to block IL-6 cytokine signaling to study its effects on glial cell reactivity5. AG 490 has also been used as a JAK2 inhibitor in human umbilical vein endothelial cells6.

Packaging

5 mg in glass bottle
25 mg in poly bottle

Biochem/physiol Actions

Jak-2 protein tyrosine kinase (PTK) inhibitor. Inhibits interleukin 2 (IL-2) driven mitogenesis and triggers apoptosis of tumor cells in Sezary syndrome, a leukemic variant of cutaneous T cell lymphoma.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the JAKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Caution

Photosensitive

Preparation Note

Tyrphostin AG 490 is soluble in ethanol at 5 mg/ml and is insoluble in water. It is also soluble in DMSO at 10 mg/ml and yields a clear, yellow solution.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Certificate of Analysis

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Certificate of Origin

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