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T3516

Sigma-Aldrich

Thioflavin T

used as stain for amyloid

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Synonym(s):
Basic Yellow 1, Thioflavine T
Empirical Formula (Hill Notation):
C17H19ClN2S
CAS Number:
Molecular Weight:
318.86
Colour Index Number:
49005
Beilstein:
3922452
EC Number:
MDL number:
PubChem Substance ID:

form

powder

composition

Dye content, ≥65%

solubility

methanol: 1 mg/mL

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

[Cl-].CN(C)c1ccc(cc1)-c2sc3cc(C)ccc3[n+]2C

InChI

1S/C17H19N2S.ClH/c1-12-5-10-15-16(11-12)20-17(19(15)4)13-6-8-14(9-7-13)18(2)3;/h5-11H,1-4H3;1H/q+1;/p-1

InChI key

JADVWWSKYZXRGX-UHFFFAOYSA-M

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This Item
T1892F6377R6626
Thioflavin T used as stain for amyloid

Sigma-Aldrich

T3516

Thioflavin T

Thioflavine S practical grade

Sigma-Aldrich

T1892

Thioflavine S

Rhodamine B ≥95% (HPLC)

Sigma-Aldrich

R6626

Rhodamine B

composition

Dye content, ≥65%

composition

-

composition

-

composition

-

solubility

methanol: 1 mg/mL

solubility

ethanol: water (1:1): 1 mg/mL

solubility

-

solubility

H2O: 1 mg/mL

application(s)

diagnostic assay manufacturing
hematology
histology

application(s)

diagnostic assay manufacturing
hematology
histology

application(s)

diagnostic assay manufacturing
hematology
histology

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

General description

Thioflavin T is a benzothiazole dye that increases in fluorescence upon binding to amyloid. Thioflavin T has been used in histology and for protein characterization.

Application

Thioflavin T has been used to identify the presence of amyloid fibrils in samples.

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Sens. 1

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Matthew Biancalana et al.
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Intense efforts to detect, diagnose, and analyze the kinetic and structural properties of amyloid fibrils have generated a powerful toolkit of amyloid-specific molecular probes. Since its first description in 1959, the fluorescent dye Thioflavin-T (ThT) has become among the most
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Hawe, A., et al.
Pharmaceut. Res., 25, 1487-1499 (2008)

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