T3955

TNP

Name: TNP
Brand: SIGMA
Price: 255 USD
Availability: InStock

≥95% (HPLC), IP6K inhibitor, powder

Synonym(s):

N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine; N6-[(4-nitrophenyl)methyl]-N2-[[3-(trifluoromethyl)phenyl]methyl]-9H-Purine-2,6-diamine; N6-[(4-nitrophenyl)methyl]-N2-[[3-(trifluoromethyl)phenyl]methyl]-1H-Purine-2,6-diamine

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₁₆F₃N₇O₂

CAS Number:

519178-28-0

Molecular Weight:

443.38

UNSPSC Code:

12352200

PubChem Substance ID:

329826781

NACRES:

NA.77

MDL number:

MFCD16875436

Assay:

≥95% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

protect from light

Key Documents

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Product Name

TNP, ≥95% (HPLC)

SMILES string

[O-][N+](=O)c1ccc(CNc2nc(NCc3cccc(c3)C(F)(F)F)nc4[nH]cnc24)cc1

InChI key

DDSBPUYZPWNNGH-UHFFFAOYSA-N

InChI

1S/C20H16F3N7O2/c21-20(22,23)14-3-1-2-13(8-14)10-25-19-28-17(16-18(29-19)27-11-26-16)24-9-12-4-6-15(7-5-12)30(31)32/h1-8,11H,9-10H2,(H3,24,25,26,27,28,29)

assay

≥95% (HPLC)

form

powder

storage condition

protect from light

color

yellow

solubility

DMSO: ≥10 mg/mL

originator

Novartis

storage temp.

2-8°C

Quality Level

100

Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

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Show Differences

1 of 4

This Item	N144	S1697	SML0526
Sigma-Aldrich T3955 TNP	Sigma-Aldrich N144 Nitrendipine	Sigma-Aldrich S1697 SPD304	Sigma-Aldrich SML0526 EHop-016
assay ≥95% (HPLC)	assay >95%	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form powder	form powder	form solid	form powder
Quality Level 100	Quality Level 200	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. -	storage temp. 2-8°C	storage temp. 2-8°C
storage condition protect from light	storage condition -	storage condition -	storage condition -
solubility DMSO: ≥10 mg/mL	solubility methanol: 15 mg/mL, DMSO: 17.5 mg/mL, H₂O: insoluble	solubility H₂O: >5 mg/mL	solubility DMSO: 10 mg/mL, clear

Biochem/physiol Actions

Potent and selective IP6K inhibitor; less selective inhibitor of IP3K.

TNP is a potent and selective IP6K inhibitor; less selective inhibitor of IP3K. Discovery of TNP as an inositol trisphosphate (IP3) kinase inhibitor was first reported in 2002, However, a recent reference shows that TNP is more potent as an IP6K inhibitor, making it valuable for study of inositol pyrophosphates.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

TNP is soluble in DMSO at a concentration that is greater than or equal to 10 mg/ml.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Improving Transitions of Care for Veterans Transferred to Tertiary VA Medical Centers.

Robert E Burke et al.

American journal of medical quality : the official journal of the American College of Medical Quality, 33(2), 147-153 (2017-07-12)

Veterans are often transferred from "spoke" Veterans Administration (VA) clinics or hospitals to "hub" tertiary VA hospitals for advanced inpatient care, but they face significant barriers to safe transitions home. The Transitions Nurse Program was developed as an intervention to

FcεR1-mediated mast cell reactivity is amplified through prolonged Toll-like receptor-ligand treatment.

Rohit Saluja et al.

PloS one, 7(8), e43547-e43547 (2012-08-24)

Mast cell-derived mediators mediate several of the pathological features of asthma. Microbial infections induce asthma exacerbations in which the contribution of mast cells remains incomprehensible. In this study we have investigated the characteristic expression pattern of Toll-like receptors (TLRs) 1-9

The Effects of Transdermal Nicotine Patches on the Cardiorespiratory and Lactate Responses During Exercise from Light to Moderate Intensity: Implications for Exercise Prescription during Smoking Cessation.

Takashi Nakagata et al.

Medicina (Kaunas, Lithuania), 55(7) (2019-07-10)

Background and objectives: Exercise can help ease withdrawal symptoms of smokers. However, there is little information about the physiological responses, such as cardiorespiratory and lactate (La) responses, during exercise from light to moderate intensity combined with transdermal nicotine patches (TNPs)

Complement-activating IgM enhances the humoral but not the T cell immune response in mice.

Zhoujie Ding et al.

PloS one, 8(11), e81299-e81299 (2013-11-20)

IgM antibodies specific for a certain antigen can enhance antibody responses when administered together with this antigen, a process believed to require complement activation by IgM. However, recent data show that a knock-in mouse strain, Cμ13, which only produces IgM

Identifying trade-offs between biodiversity conservation and ecosystem services delivery for land-use decisions.

Constance Fastré et al.

Scientific reports, 10(1), 7971-7971 (2020-05-16)

Sustainable land-use management must account for the potential trade-offs between biodiversity conservation, productive land uses and ecosystem services. In this study, we used Marxan with Zones to generate land use plans that optimize conservation, farming and forestry land uses to

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TNP