T4376
N-p-Tosyl-L-phenylalanine chloromethyl ketone
powder, ≥97% (TLC)
Synonym(s):
(S)-1-Chloro-3-tosylamido-4-phenyl-2-butanone, (S)-1-Chloro-4-phenyl-3-tosylamido-2-butanone, TPCK, Tosyl-L-phenylalanyl-chloromethane
About This Item
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product name
N-p-Tosyl-L-phenylalanine chloromethyl ketone, ≥97% (TLC), powder
biological source
synthetic
assay
≥97% (TLC)
form
powder
potency
10-100 μM effective concentration
color
white
mp
106-108 °C (lit.)
solubility
DMSO: >10 mg/mL (stable for several months at 4°C.)
ethanol: 20 mg/mL
storage temp.
−20°C
SMILES string
Cc1ccc(cc1)S(=O)(=O)N[C@@H](Cc2ccccc2)C(=O)CCl
InChI
1S/C17H18ClNO3S/c1-13-7-9-15(10-8-13)23(21,22)19-16(17(20)12-18)11-14-5-3-2-4-6-14/h2-10,16,19H,11-12H2,1H3/t16-/m0/s1
InChI key
MQUQNUAYKLCRME-INIZCTEOSA-N
Gene Information
human ... NFKB1(4790) , NKAP(79576) , NKRF(55922) , NOS2(4843) , PTGS2(5743)
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General description
Application
- to investigate whether transcription factor NFκB is involved in renalase expression
- to test the role of NF-κB activation
- to study its inhibitory effect on chymotrypsin
Biochem/physiol Actions
Packaging
Caution
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Analytical Enzyme Chymotrypsin: Chymotrypsin is produced in the acinar cells of the pancreas as the inactive precursor, chymotrypsinogen.
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