T4567

Sigma-Aldrich

Transforming Growth Factor-β Soluble Receptor III human

>97% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Synonym(s):
TGF-β sRIII
MDL number:
Pricing and availability is not currently available.

biological source

human

recombinant

expressed in NSO cells

assay

>97% (SDS-PAGE)

form

lyophilized powder

mol wt

100 kDa by SDS-PAGE (glycosylation)
predicted mol wt 84 kDa

packaging

pkg of 1 mg

storage condition

avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)

impurities

endotoxin, tested

UniProt accession no.

storage temp.

−20°C

Gene Information

human ... TGFBR3(7049)

Application

Transforming Growth Factor-β soluble receptor III human can be used to study TGF-β- mediated signal tranduction.

Biochem/physiol Actions

Transforming Growth Factor-β soluble receptor III human also known as betaglycan facilitates as an inhibin co-receptor with ActRII and mediates functional antagonism of activin signalling.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 5 mg bovine serum albumin

Analysis Note

The receptor-mediated activity is measured by its ability to inhibit the TGF-β2 bioactivity in HT-2 cells.

RIDADR

NONH for all modes of transport

WGK Germany

3

Certificate of Analysis
Certificate of Origin
M L Tsang et al.
Cytokine, 7(5), 389-397 (1995-07-01)
Recombinant human transforming growth factor soluble receptor Type II (rhTGF-beta sRII) corresponding to the 159 amino acid extracellular domain of hTGF-beta RII has been expressed in insect cells using the baculovirus expression system or in a mouse myeloma cell line....
K A Lewis et al.
Nature, 404(6776), 411-414 (2000-04-04)
Activins and inhibins, structurally related members of the TGF-beta superfamily of growth and differentiation factors, are mutually antagonistic regulators of reproductive and other functions. Activins bind specific type II receptor serine kinases (ActRII or IIB) to promote the recruitment and...
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