T5168
Anti-TUBA4A (TUBA1) Antibody

mouse monoclonal, B-5-1-2
Synonym(s):
Alpha Tubulin Antibody Sigma, Anti Tubulin Sigma, Tubulin Antibody Sigma, Tubulin Antibody Sigma - Monoclonal Anti-α-Tubulin antibody produced in mouse
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Product Name
Monoclonal Anti-α-Tubulin antibody produced in mouse, ascites fluid, clone B-5-1-2
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
B-5-1-2, monoclonal
mol wt
antigen ~50 kDa
contains
15 mM sodium azide
species reactivity
mouse, chicken, Chlamydomonas, African green monkey, human, rat, bovine, sea urchin, kangaroo rat
enhanced validation
independent ( Antibodies)
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technique(s)
indirect immunofluorescence: 1:2,000 using cultured human or chicken fibroblasts
radioimmunoassay: suitable
western blot: 1:4,000 using human fibroblast cell extract
isotype
IgG1
UniProt accession no.
application(s)
research pathology
shipped in
dry ice
Storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... TUBA4A(7277)
mouse ... Tuba1a(22142)
rat ... Tuba1a(64158)
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This Item | T9026 | T7451 | T5293 |
---|---|---|---|
conjugate unconjugated | conjugate unconjugated | conjugate unconjugated | conjugate unconjugated |
clone B-5-1-2, monoclonal | clone DM1A, monoclonal | clone 6-11B-1, monoclonal | clone 2-28-33, monoclonal |
antibody form ascites fluid | antibody form ascites fluid | antibody form purified immunoglobulin | antibody form ascites fluid |
Gene Information human ... TUBA4A(7277) | Gene Information human ... TUBA4A(7277) | Gene Information human ... TUBA4A(7277) | Gene Information human ... TUBB1(81027), TUBB2A(7280), TUBB2C(10383) |
species reactivity mouse, chicken, Chlamydomonas, African green monkey, human, rat, bovine, sea urchin, kangaroo rat | species reactivity yeast, mouse, amphibian, human, rat, chicken, fungi, bovine | species reactivity bovine, frog, invertebrates, human, hamster, mouse, protista, pig, monkey, chicken, rat, plant | species reactivity Ciona intestinalis, rat, chicken, Caenorhabditis elegans, Strongylocentrotus purpuratus, bovine, human |
biological source mouse | biological source mouse | biological source mouse | biological source mouse |
General description
Specificity
Immunogen
Application
- In immunofluorescence Analysis
- In western blotting/ Immunoblotting
- For immunolabelling cells in electron microscopy
Biochem/physiol Actions
α-Tubulin is a key regulator of cytoskeletal proteins. It mediates cellular developmental stages such as proliferation, migration, signalling and also maintains the shape of the cell. α-Tubulin controls trafficking, signaling and cellular tensegrity mediated by microtubules. The encoded protein is associated with the development and progression of cancer. α-Tubulin acetylation potentiates the metastatic property of breast cancer. Mutation in TUBA4A is associated with the development of various types of cancers, such as oral cancer, breast cancer, rectal cancer, lung cancer and prostate cancer. In addition, variation in the TUBA4A leads to sporadic amyotrophic lateral sclerosis (ALS).
Microtubules function as structural and mobile elements in mitosis, intracellular transport, flagellar movement and the cytoskeleton.
Physical form
Storage and Stability
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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