T6140

N-(p-Tosyl)-Gly-Pro-Lys 4-nitroanilide acetate salt

Name: N-(p-Tosyl)-Gly-Pro-Lys 4-nitroanilide acetate salt
Brand: SIGMA
Price: 191 USD
Availability: InStock

plasmin substrate, chromogenic, ≥98% (TLC), powder

Synonym(s):

N-Tosylglycyl-L-prolyl-L-lysine 4-nitroanilide acetate salt

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$643.00

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About This Item

Linear Formula:

C₂₆H₃₄N₆O₇S · C₂H₄O₂

CAS Number:

88793-79-7

Molecular Weight:

634.70

NACRES:

NA.32

PubChem Substance ID:

24900352

UNSPSC Code:

12352204

EC Number:

289-446-7

MDL number:

MFCD00057232

Key Documents

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Product Name

N-(p-Tosyl)-Gly-Pro-Lys 4-nitroanilide acetate salt, plasmin substrate

InChI key

KPGSNEYSJPIZCW-SJEIDVEUSA-N

InChI

1S/C26H34N6O7S.C2H4O2/c1-18-7-13-21(14-8-18)40(38,39)28-17-24(33)31-16-4-6-23(31)26(35)30-22(5-2-3-15-27)25(34)29-19-9-11-20(12-10-19)32(36)37;1-2(3)4/h7-14,22-23,28H,2-6,15-17,27H2,1H3,(H,29,34)(H,30,35);1H3,(H,3,4)/t22-,23-;/m0./s1

SMILES string

CC(O)=O.Cc1ccc(cc1)S(=O)(=O)NCC(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)Nc3ccc(cc3)[N+]([O-])=O

assay

≥98% (TLC)

form

powder

solubility

ethanol: 50 mg/mL, colorless to yellow

storage temp.

−20°C

Quality Level

200

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Show Differences

1 of 4

This Item	96286	B6760	M4765
Sigma-Aldrich T6140 N-(p-Tosyl)-Gly-Pro-Lys 4-nitroanilide acetate salt	Sigma-Aldrich 96286 Z-Gly-Pro-4-nitroanilide	Sigma-Aldrich B6760 N-Benzoyl-L-tyrosine p-nitroanilide	Sigma-Aldrich M4765 N-Methoxysuccinyl-Ala-Ala-Pro-Val p-nitroanilide
assay ≥98% (TLC)	assay ≥99.0% (TLC)	assay ≥98.0% (TLC)	assay ≥98% (HPLC)
solubility ethanol: 50 mg/mL, colorless to yellow	solubility -	solubility -	solubility DMF: soluble 25 mg/mL, clear, colorless to light yellow
Quality Level 200	Quality Level 100	Quality Level 200	Quality Level 300
form powder	form powder or crystals	form powder	form powder
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C

General description

A chromogenic substrate for plasmin.

Application

N-(p-Tosyl)-Gly-Pro-Lys 4-nitroanilide acetate salt has been used:

as a substrate for examining the amidolytic activity of aprE2,[1] aprE5-41[2]
as a substrate for serine protease and fibrinogenolytic assays[3]
as a substrate for plasmin assay[4]

Biochem/physiol Actions

N-(p-Tosyl)-Gly-Pro-Lys 4-nitroanilide acetate salt is a chromogenic substrate for plasmin assay,[4] serine protease enzyme activity and fibrinogenolytic assays.[3]

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Construction of a novel Staphylokinase (SAK) mutant with low immunogenicity and its evaluation in rhesus monkey.

Min Wang et al.

International journal of biological macromolecules, 146, 781-789 (2019-11-16)

The heterologous nature of SAK, a thrombolytic drug, elicits high titers of neutralizing antibodies, which limits its clinical use. Here, we aim to establish a SAK mutant with equivalent activity to the wild type but reduced antigenicity, which may allow

Overexpression of aprE2, a Fibrinolytic Enzyme Gene from Bacillus subtilis CH3-5, in Escherichia coli and the Properties of AprE2.

Jeong SJ, et al.

Journal of microbiology and biotechnology, 24(7), 969-978 (2014)

Streptococcus pneumoniae choline-binding protein E interaction with plasminogen/plasmin stimulates migration across the extracellular matrix.

Attali C, et al.

Infection and Immunity, 76(2), 466-476 (2008)

A bi-functional anti-thrombosis protein containing both direct-acting fibrin (ogen) olytic and plasminogen-activating activities

Yang H, et al.

PLoS ONE, 6(3), e17519-e17519 (2011)

PgFur participates differentially in expression of virulence factors in more virulent A7436 and less virulent ATCC 33277 Porphyromonas gingivalis strains.

Michał Śmiga et al.

BMC microbiology, 19(1), 127-127 (2019-06-13)

Porphyromonas gingivalis is considered a keystone pathogen responsible for chronic periodontitis. Although several virulence factors produced by this bacterium are quite well characterized, very little is known about regulatory mechanisms that allow different strains of P. gingivalis to efficiently survive

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N-(p-Tosyl)-Gly-Pro-Lys 4-nitroanilide acetate salt