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T6397

Sigma-Aldrich

3,3′,5-Triiodo-L-thyronine sodium salt

powder, BioReagent, suitable for cell culture

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Synonym(s):
Liothyronine, O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine sodium salt, T3
Empirical Formula (Hill Notation):
C15H11I3NNaO4
CAS Number:
Molecular Weight:
672.96
Beilstein/REAXYS Number:
8179867
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

biological source

synthetic

Quality Level

product line

BioReagent

assay

≥95%

form

powder

potency

0.02-50 ng/mL (lit.)

technique(s)

cell culture | mammalian: suitable

solubility

ethanol/1 M HCl (4:1): 10 mg/mL, clear, colorless to yellow

shipped in

ambient

storage temp.

−20°C

SMILES string

[Na+].N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C([O-])=O

InChI

1S/C15H12I3NO4.Na/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;/h1-4,6,12,20H,5,19H2,(H,21,22);/q;+1/p-1/t12-;/m0./s1

InChI key

SBXXSUDPJJJJLC-YDALLXLXSA-M

Gene Information

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This Item
T5516T2877L0700000
3,3′,5-Triiodo-L-thyronine ≥95% (HPLC), powder

T2877

3,3′,5-Triiodo-L-thyronine

Liothyronine sodium European Pharmacopoeia (EP) Reference Standard

L0700000

Liothyronine sodium

assay

≥95%

assay

≥90% (HPLC)

assay

≥95% (HPLC)

assay

-

product line

BioReagent

product line

-

product line

-

product line

-

Quality Level

200

Quality Level

200

Quality Level

-

Quality Level

-

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

transfection: suitable

technique(s)

-

form

powder

form

powder

form

powder

form

-

General description

3,3′,5′-Triiodo-L-thyronine (T3) is an endocrine hormone produced by the thyroid gland and is regarded as an active thyroid hormone at cellular level. Thyroxine (T4) serves as a precursor for T3 and is generated in extrathyroidal tissues.

Application

3,3′,5-Triiodo-L-thyronine sodium salt has been used for inducing thyroid hormone manipulations in mice. It has also been used In cell culturing of hippocampal, retinal, proximal tubule and glomerular explant.

Biochem/physiol Actions

3,3′,5′-Triiodo-L-thyronine (T3) increases the rates of protein synthesis, stimulates the breakdown of cholesterol and effects embryonic development. In cell culture, T3 regulates cell differentiation and protein expression. The interaction of T3 with nonhistone proteins in the chromatin initiates the thyroid hormone activity. Thyroid hormones regulate the differentiation and development of tissues and affect a number of metabolic processes. The level of circulating T3 hormone is reduced in hypothyroidism.

Physical form

powder-20 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw, solution stable 2-8 °C, 30 days

Reconstitution

To prepare 20 μg/ml stock solution: add 1ml 1N NaOH per mg 3,3′, 5-triiodo-L-thyronine; gently swirl to dissolve. To this, add 49 ml sterile medium per ml 1N NaOH added.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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