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T6779

Sigma-Aldrich

Tolmetin sodium salt dihydrate

Synonym(s):
1-Methyl-5-(p-toluoyl)pyrrole-2-acetic acid sodium salt dihydrate
Linear Formula:
C15H14NO3Na · 2H2O
CAS Number:
Molecular Weight:
315.30
EC Number:
MDL number:
PubChem Substance ID:

solubility

H2O: soluble 50 mg/mL, clear, colorless

SMILES string

[Na+].[H]O[H].[H]O[H].Cc1ccc(cc1)C(=O)c2ccc(CC([O-])=O)n2C

InChI

1S/C15H15NO3.Na.2H2O/c1-10-3-5-11(6-4-10)15(19)13-8-7-12(16(13)2)9-14(17)18;;;/h3-8H,9H2,1-2H3,(H,17,18);;2*1H2/q;+1;;/p-1

InChI key

QQILXENAYPUNEA-UHFFFAOYSA-M

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Application

An NSAID. Circumvents MRP-mediated multidrug resistance. Significantly increases the cytotoxicity of the anthracyclines (doxorubicin, daunorubicin and epirubicin), as well as teniposide, VP-16 and vincristine.

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More documents

Quotes and Ordering

Kishore Kumar Hotha et al.
Biomedical chromatography : BMC, 24(10), 1100-1107 (2010-09-21)
A highly sensitive, rapid assay method has been developed and validated for the simultaneous estimation of tolmetin (TMT) and MED5 in human plasma with liquid chromatography coupled to tandem mass spectrometry with electrospray ionization in the positive-ion mode. A simple
Mitra Jelvehgari et al.
Pharmaceutical development and technology, 15(1), 71-79 (2009-06-10)
Ethylcellulose microparticles containing tolmetin sodium, an anti-inflammatory drug, were prepared by a solvent diffusion method based on the formation of multiple W/O(1)/O(2)-emulsion. The drug used was TOL, which is water-soluble and n-hexane was used as the non-solvent. Important parameters in
Cláudia Nunes et al.
The journal of physical chemistry. B, 115(43), 12615-12623 (2011-09-23)
This work focuses on the application of different biophysical techniques to study the interaction of tolmetin with membrane mimetic models of different dimensionality (liposomes, monolayers, and supported lipid bilayers) composed of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), used as a representative phospholipid of natural
David R Ely et al.
International journal of pharmaceutics, 414(1-2), 157-160 (2011-05-24)
In this work, near infrared (NIR) hyperspectral imaging was used to quantify the spatial distribution of drug in tablets containing tolmetin sodium dihydrate. Hyperspectral data cubes were generated by imaging the same spatial region of a sample while illuminated by
R Scott Obach
Drug metabolism and disposition: the biological fate of chemicals, 37(8), 1581-1586 (2009-05-15)
During an investigation of the in vitro glucuronidation of benoxaprofen by human liver S-9 fraction, an unusual drug-related entity possessing a protonated molecular ion that was 74 mass units greater than the parent drug was observed. It was identified as

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