Transforming Growth Factor-β1 human

TGF-β1, recombinant, expressed in CHO cells, powder, suitable for cell culture

TGF-β1, hTGF-β1
MDL number:
Pricing and availability is not currently available.

Quality Level

biological source



expressed in CHO cells


≥98% (SDS-PAGE)




≤0.05 ng/mL ED50


endotoxin tested

mol wt

protein 25 kDa


pkg of 2 μg
pkg of 50 μg

storage condition

avoid repeated freeze/thaw cycles


cell culture | mammalian: suitable


<1 EU/μg

UniProt accession no.

storage temp.


Gene Information

human ... TGFB1(7040)

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General description

Tgfb1 (transforming growth factor-β1 human) is a 25kDa peptide encoded by the gene mapped to human chromosome 19q13.2. TGF-β1 polypeptide is produced as a precursor with hydrophobic signal sequence, pro-region and mature peptide. Cleavage of the precursor at tetrabasic cleavage site results in monomers of carboxy-terminal 112 amino acids. The biologically active form of Tgfb1 exists as a disulphide-linked homodimer. In mammals, three isoforms of TGF-β has been identified : TGF-β1, TGF-β2 and TGF-β3.


Transforming Growth Factor-β1 human has been used in
  • reporter gene assay.
  • in vitro transfection.
  • to study the effect of transforming growth factor-β1 (TGF-β1) on gene array analysis of renal cells.
  • to study the association of TGF-β1 with shear stress-dependent upregulation of tissue inhibitor of metalloproteinase-1 in microvascular endothelial cells.
  • to study the interaction between TGF-β1 activation and myofibroblast formation.

Biochem/physiol Actions

TGF-β1 is a multifunctional peptide capable of influencing cell proliferation, tissue growth, differentiation, and other functions in a wide range of cell types. TGF-β1 plays a fundamental role in differentiation by involvement in adipogenesis, myogenesis, chondrogenesis, osteogenesis, epithelial cell differentiation and immune cell function. All cells possess a specific TGF-β1 receptor. Both transformed and non-neoplastic tissues release transforming growth factors.The multi-modal nature of TGF-β1 is seen in its ability to stimulate or inhibit cellular proliferation. TGF-β1 is associated with the developmental and metastasis of colorectal cancer.
Transforming growth factor-β1 (TGF-β1) is produced by many cell types, but is reported to be most concentrated in mammalian platelets, where it is present at approximately four times the level of TGF-β2.

Physical form

Lyophilized from a 0.2 μm filtered aqueous solution.

Analysis Note

The biological activity of TGF-β1 is measured in culture by inhibition of mouse IL-4-dependent proliferation of mouse HT-2 cells.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves


NONH for all modes of transport

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Transforming Growth Factor-β Induces Renal Epithelial
Jagged-1 Expression in Fibrotic Disease
Morrissey J, et al.
Journal of the American Society of Nephrology, 13, 1499- 1508 (2002)
Regulation of α-Smooth Muscle Actin Expression in Granulation Tissue Myofibroblasts Is Dependent on the Intronic CArG Element and the Transforming Growth Factor-β1 Control Element
Tomasek JJ, et al.
The American Journal of Pathology, 166, 1343-1351 (2005)
Tibor Kempf et al.
Clinical chemistry, 53(2), 284-291 (2006-12-23)
Growth-differentiation factor 15 (GDF15) is a member of the transforming growth factor beta (TGF-beta) cytokine superfamily. There has been increasing interest in using circulating GDF15 as a biomarker in patients, for example those with cardiovascular disease. We developed an IRMA...
Differential Effects of Transforming Growth Factor-β1 on Cellular Proliferation in the Developing Prostate
Tomlinson DC, et al.
Endocrinology, 145, 4292-4300 (2004)
Transforming growth factor β and platelet-derived growth factor modulation of myofibroblast development from corneal fibroblasts in vitro
Singh V, et al.
Experimental Eye Research, 120, 152-160 (2014)
Naive pluripotent stem cells are located within the epiblast of mature blastocysts. These primitive “ground-state” cells may be cultured in vitro using specialized media and small molecule inhibitors.
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