T7313

1-[2-(Trifluoromethyl)phenyl]imidazole

• Synonym(s): TRIM
• Empirical Formula (Hill Notation): C₁₀H₇F₃N₂
• CAS Number: 25371-96-4
• Molecular Weight: 212.17
• NACRES: NA.77
• PubChem Substance ID: 24278754
• UNSPSC Code: 12352202
• MDL number: MFCD00041206

Properties

• biological source: synthetic (organic)
• Quality Segment: 200
• assay: ≥98% (GC)
• form: solid
• solubility: DMSO: soluble 30 mg/mL
• storage temp.: 2-8°C
• SMILES string: FC(F)(F)c1ccccc1-n2ccnc2
• InChI: 1S/C10H7F3N2/c11-10(12,13)8-3-1-2-4-9(8)15-6-5-14-7-15/h1-7H
• InChI key: WZBWBNCQUTXYEL-UHFFFAOYSA-N
• Gene Information: human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)

Description

Biochem/physiol Actions

Potent nitric oxide synthase inhibitor.

Potent nitric oxide synthase inhibitor. Because of the putative involvement of nitric oxide in depression and stress syndromes, TRIM was studied for its antidepressant effects, and found to reduce manifestations of stress in an animal model as well as fluoxetine.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Codes: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): dust mask type N95 (US), Eyeshields, Gloves