T7455

Tolvaptan

≥98% (HPLC), V2-selective antagonist, powder

• Synonym(s): N-[4-[(7-Chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide, OPC 41061
• Empirical Formula (Hill Notation): C₂₆H₂₅ClN₂O₃
• CAS Number: 150683-30-0
• Molecular Weight: 448.94
• UNSPSC Code: 51111800
• PubChem Substance ID: 329826866
• NACRES: NA.77
• MDL number: MFCD09838782
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Product Name: Tolvaptan, ≥98% (HPLC), powder
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to tan
• solubility: DMSO: ≥15 mg/mL
• originator: Sanofi Aventis
• storage temp.: 2-8°C
• SMILES string: Cc1ccccc1C(=O)Nc2ccc(c(C)c2)C(=O)N3CCCC(O)c4cc(Cl)ccc34
• InChI: 1S/C26H25ClN2O3/c1-16-6-3-4-7-20(16)25(31)28-19-10-11-21(17(2)14-19)26(32)29-13-5-8-24(30)22-15-18(27)9-12-23(22)29/h3-4,6-7,9-12,14-15,24,30H,5,8,13H2,1-2H3,(H,28,31)
• InChI key: GYHCTFXIZSNGJT-UHFFFAOYSA-N
• Gene Information: human ... AVPR2(554)

Description

Application

Tolvaptan has been used as a V2-selective antagonist for studying its effect on hypertension in mice.

Biochem/physiol Actions

Tolvaptan (OPC 41061) is a potent, orally active non-peptide vasopressin V2 selective antagonist. IC50 = 3 nM at the rat V2 receptor; 29 times more selective for the V2 than for V1a. Tolvaptan has also been shown to inhibit the development of polycystic kidney disease in several animal models.

Tolvaptan is a potent, orally active non-peptide vasopressin V2 receptor antagonist.

Features and Benefits

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

Tolvaptan is soluble in DMSO at a concentration that is greater than or equal to 15 mg/ml.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable