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T7697

I-OMe-Tyrphostin AG 538

solid

Synonym(s):

α-Cyano-(3-methoxy-4-hydroxy-5-iodocinnamoyl)-(3′,4′-dihydroxyphenyl)ketone, I-OMe-AG 538

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5 MG

$190.00

$190.00

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About This Item

Empirical Formula (Hill Notation):
C17H12INO5
CAS Number:
1094048-77-7
Molecular Weight:
437.19
MDL number:
MFCD03453582
UNSPSC Code:
12352203
PubChem Substance ID:
24278758
NACRES:
NA.77

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form

solid

Quality Level

100

solubility

DMSO: 50 mg/mL

storage temp.

−20°C

SMILES string

COc1cc(cc(I)c1O)\C=C(/C#N)C(=O)c2ccc(O)c(O)c2

InChI

1S/C17H12INO5/c1-24-15-6-9(5-12(18)17(15)23)4-11(8-19)16(22)10-2-3-13(20)14(21)7-10/h2-7,20-21,23H,1H3/b11-4+

InChI key

HSRMHXWCTRFVHK-NYYWCZLTSA-N

Gene Information

human ... IGF1(3479), IGF1R(3480)

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This Item
T7665658403C0987
I-OMe-Tyrphostin AG 538 solid

Sigma-Aldrich

T7697

I-OMe-Tyrphostin AG 538

Tyrphostin 51 ≥98%

Sigma-Aldrich

T7665

Tyrphostin 51

AG 538 A potent, cell-premeable, reversible, and competitive inhibitor of IGF-1 receptor kinase (IC50 = 400 nM).

Sigma-Aldrich

658403

AG 538

CGP-13501 ≥98% (HPLC), solid

Sigma-Aldrich

C0987

CGP-13501

form

solid

form

powder

form

solid

form

solid

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

-

solubility

DMSO: 50 mg/mL

solubility

DMSO: soluble 5 mg of Tyrphostin 51 in 0.1 ml of solvent, clear, orange to red

solubility

DMSO: 5 mg/mL

solubility

DMSO: soluble 24 mg/mL

Gene Information

human ... IGF1(3479), IGF1R(3480)

Gene Information

human ... CDK2(1017), EGFR(1956)

Gene Information

-

Gene Information

human ... GABBR1(2550), GABBR2(9568)

Application

I-OMe-Tyrphostin AG 538 has been used as a cell signaling inhibitor in PC-1 cell lines[1]. It has also been used in high throughput screening assays for IGF1R inhibitors[2].

Biochem/physiol Actions

Insulin growth factor 1 (IGF-1) receptor protein tyrosine kinase inhibitor.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Preparation Note

I-OMe-Tyrphostin AG 538 is soluble in DMSO at 50 mg/ml.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
012K3785
012K378501

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Sara M Garrett et al.
PloS one, 14(11), e0225422-e0225422 (2019-11-26)
Type 2 insulin-like growth factor (IGF-II) levels are increased in fibrosing lung diseases such as idiopathic pulmonary fibrosis (IPF) and scleroderma/systemic sclerosis-associated pulmonary fibrosis (SSc). Our goal was to investigate the contribution of IGF receptors to IGF-II-mediated fibrosis in these
R Moriev et al.
Acta naturae, 5(2), 90-99 (2013-07-03)
The aim of this study was to identify small molecule compounds that inhibit the kinase activity of the IGF1 receptor and represent novel chemical scaffolds, which can be potentially exploited to develop drug candidates that are superior to the existing
Haifeng Geng et al.
PloS one, 6(12), e29504-e29504 (2012-01-05)
Small molecules have been identified as potential therapeutic agents for lysosomal storage diseases (LSDs), inherited metabolic disorders caused by defects in proteins that result in lysosome dysfunctional. Some small molecules function assisting the folding of mutant misfolded lysosomal enzymes that
Mahsa Hamzeh et al.
The Journal of endocrinology, 209(1), 55-64 (2011-01-12)
Androgens are the primary regulators of epididymal structure and functions. In the classical view of androgen action, binding of androgen to the intracellular androgen receptor (AR) produces the receptor-steroid complex that has high affinity for DNA response elements and regulates

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