T7697

Sigma-Aldrich

I-OMe-Tyrphostin AG 538

solid

Synonym(s):
α-Cyano-(3-methoxy-4-hydroxy-5-iodocinnamoyl)-(3′,4′-dihydroxyphenyl)ketone, I-OMe-AG 538
Empirical Formula (Hill Notation):
C17H12INO5
Molecular Weight:
437.19
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

form

solid

solubility

DMSO: 50 mg/mL

storage temp.

−20°C

SMILES string

COc1cc(cc(I)c1O)\C=C(/C#N)C(=O)c2ccc(O)c(O)c2

InChI

1S/C17H12INO5/c1-24-15-6-9(5-12(18)17(15)23)4-11(8-19)16(22)10-2-3-13(20)14(21)7-10/h2-7,20-21,23H,1H3/b11-4+

InChI key

HSRMHXWCTRFVHK-NYYWCZLTSA-N

Gene Information

Application

I-OMe-Tyrphostin AG 538 has been used as a cell signaling inhibitor in PC-1 cell lines. It has also been used in high throughput screening assays for IGF1R inhibitors.

Packaging

5 mg in glass bottle

Biochem/physiol Actions

Insulin growth factor 1 (IGF-1) receptor protein tyrosine kinase inhibitor.

Preparation Note

I-OMe-Tyrphostin AG 538 is soluble in DMSO at 50 mg/ml.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Sara M Garrett et al.
PloS one, 14(11), e0225422-e0225422 (2019-11-26)
Type 2 insulin-like growth factor (IGF-II) levels are increased in fibrosing lung diseases such as idiopathic pulmonary fibrosis (IPF) and scleroderma/systemic sclerosis-associated pulmonary fibrosis (SSc). Our goal was to investigate the contribution of IGF receptors to IGF-II-mediated fibrosis in these...
Haifeng Geng et al.
PloS one, 6(12), e29504-e29504 (2012-01-05)
Small molecules have been identified as potential therapeutic agents for lysosomal storage diseases (LSDs), inherited metabolic disorders caused by defects in proteins that result in lysosome dysfunctional. Some small molecules function assisting the folding of mutant misfolded lysosomal enzymes that...
R Moriev et al.
Acta naturae, 5(2), 90-99 (2013-07-03)
The aim of this study was to identify small molecule compounds that inhibit the kinase activity of the IGF1 receptor and represent novel chemical scaffolds, which can be potentially exploited to develop drug candidates that are superior to the existing...
Mahsa Hamzeh et al.
The Journal of endocrinology, 209(1), 55-64 (2011-01-12)
Androgens are the primary regulators of epididymal structure and functions. In the classical view of androgen action, binding of androgen to the intracellular androgen receptor (AR) produces the receptor-steroid complex that has high affinity for DNA response elements and regulates...

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service

Social Media

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon

MilliporeSigma

Research. Development. Production.

We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.

© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.

Reproduction of any materials from the site is strictly forbidden without permission.