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T8880

Sigma-Aldrich

Thymidylyl(3′→5′)thymidine ammonium salt

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Synonym(s):
TpT
Linear Formula:
C20H27N4O12P · NH3
CAS Number:
Molecular Weight:
563.45
MDL number:
PubChem Substance ID:

assay

~99%

form

solid

storage temp.

−20°C

SMILES string

N.CC1=CN([C@H]2C[C@H](O)[C@@H](COP(O)(=O)O[C@H]3C[C@@H](O[C@@H]3CO)N4C=C(C)C(=O)NC4=O)O2)C(=O)NC1=O

InChI

1S/C20H27N4O12P.H3N/c1-9-5-23(19(29)21-17(9)27)15-3-11(26)14(35-15)8-33-37(31,32)36-12-4-16(34-13(12)7-25)24-6-10(2)18(28)22-20(24)30;/h5-6,11-16,25-26H,3-4,7-8H2,1-2H3,(H,31,32)(H,21,27,29)(H,22,28,30);1H3/t11-,12-,13+,14+,15+,16+;/m0./s1

InChI key

TUUIEHHWVRHMDA-JQQQFMHGSA-N

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Ruzanna Y Atoyan et al.
Experimental dermatology, 16(8), 671-677 (2007-07-11)
It was previously reported that telomere homologue oligonucleotides (T-oligos) can induce a variety of cellular responses in skin including increased melanogenesis. To assess the effects of T-oligos on hair pigmentation, we administered thymidine dinucleotide (pTT), one-third of the TTAGGG telomere
C A Smith et al.
The Journal of biological chemistry, 273(34), 21933-21940 (1998-08-15)
The role of photoproduct structure, 3' --> 5' exonuclease activity, and processivity on polynucleotide synthesis past photoproducts of thymidylyl-(3' --> 5')-thymidine was investigated. Both Moloney murine leukemia virus reverse transcriptase and 3' --> 5' exonuclease-deficient (exo-) Vent polymerase were blocked
D A Goukassian et al.
The Journal of investigative dermatology, 112(1), 25-31 (1999-01-14)
The tumor suppressor protein p53 participates in DNA repair and cell cycle regulation in response to injuries like ultraviolet (UV) irradiation. We have previously reported that the thymidine dinucleotide (pTpT), a common target for DNA photoproduct formation by UV light
Yu Kay Law et al.
Biophysical journal, 94(9), 3590-3600 (2008-01-15)
It was recently shown that thymine dimers in the all-thymine oligonucleotide (dT)(18) are fully formed in <1 ps after ultraviolet excitation. The speed and low quantum yield of this reaction suggest that only a small fraction of the conformers of
Sunshine C Silver et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 15(6), 943-955 (2010-04-21)
Spore photoproduct lyase (SP lyase), a member of the radical S-adenosylmethionine superfamily of enzymes, catalyzes the repair of 5-thyminyl-5,6-dihydrothymine [spore photoproduct (SP)], a type of UV-induced DNA damage unique to bacterial spores. The anaerobic purification and characterization of Clostridium acetobutylicum

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