T9025

Thioridazine hydrochloride

≥99%

• Synonym(s): 10-[2-(1-Methyl-2-piperidyl)ethyl]-2-(methylthio)-10H-phenothiazine hydrochloride
• Empirical Formula (Hill Notation): C₂₁H₂₆N₂S₂ · HCl
• CAS Number: 130-61-0
• Molecular Weight: 407.04
• EC Number: 204-992-8
• MDL number: MFCD00012655
• PubChem Substance ID: 57654711
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥99%
• solubility: H₂O: soluble 250 mg plus 5 ml of solvent, clear, colorless to faintly yellow; chloroform: soluble; diethyl ether: insoluble; ethanol: soluble; methanol: soluble
• SMILES string: Cl.CSc1ccc2Sc3ccccc3N(CCC4CCCCN4C)c2c1
• InChI: 1S/C21H26N2S2.ClH/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23;/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3;1H
• InChI key: NZFNXWQNBYZDAQ-UHFFFAOYSA-N
• Gene Information: human ... DRD2(1813) , DRD3(1814) , DRD4(1815) , HTR2A(3356) , HTR2C(3358)

Description

Application

Thioridazine hydrochloride has been used as an intercalating agent for analyzing the integrity of double-stranded DNA (dsDNA) using square-wave voltammetry (SWV) techniques. Thioridazine hydrochloride has also been used as a positive control for the inhibition of hepatic enzyme cytochrome P4502D6 (CYP2D6) in human liver microsomes.

Packaging

5, 25 g

Biochem/physiol Actions

D₂ dopamine receptor antagonist; phenothazine antipsychotic with reduced extrapyramidal side effects; Ca²⁺ channel blocker.

Preparation Note

250 mg of thioridazine hydrochloride is soluble in 5 ml of water and yields a clear, colorless to faint yellow solution. Thioridazine hydrochloride is also soluble in methanol, ethanol, and chloroform, but it is insoluble in ether.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302
• Precautionary Statements: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves