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T9025

Sigma-Aldrich

Thioridazine hydrochloride

≥99%

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Synonym(s):
10-[2-(1-Methyl-2-piperidyl)ethyl]-2-(methylthio)-10H-phenothiazine hydrochloride
Empirical Formula (Hill Notation):
C21H26N2S2 · HCl
CAS Number:
Molecular Weight:
407.04
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥99%

solubility

H2O: soluble 250 mg plus 5 ml of solvent, clear, colorless to faintly yellow
chloroform: soluble
diethyl ether: insoluble
ethanol: soluble
methanol: soluble

SMILES string

Cl.CSc1ccc2Sc3ccccc3N(CCC4CCCCN4C)c2c1

InChI

1S/C21H26N2S2.ClH/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23;/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3;1H

InChI key

NZFNXWQNBYZDAQ-UHFFFAOYSA-N

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This Item
T8516T6764T7508
Thioridazine hydrochloride ≥99%

T9025

Thioridazine hydrochloride

Trifluoperazine dihydrochloride ≥99%, powder

T8516

Trifluoperazine dihydrochloride

Triprolidine hydrochloride ≥99%

T6764

Triprolidine hydrochloride

Tetracaine hydrochloride ≥99%

T7508

Tetracaine hydrochloride

Quality Level

100

Quality Level

100

Quality Level

200

Quality Level

200

solubility

H2O: soluble 250 mg plus 5 ml of solvent, clear, colorless to faintly yellow, diethyl ether: insoluble, methanol: soluble, chloroform: soluble

solubility

ethanol: soluble 5 mg/mL, H2O: soluble 50 mg/mL, clear, colorless to yellow, DMSO: soluble

solubility

alcohol: soluble 1 in 1.5 of solvent, chloroform: soluble 1 in less than 1 of solvent, H2O: soluble 50 mg/mL, clear, colorless to yellow

solubility

chloroform: soluble 30 parts, alcohol: soluble 40 parts, H2O: soluble mg/mL, acetone: insoluble, benzene: insoluble, diethyl ether: insoluble

Gene Information

human ... DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356), HTR2C(3358)

Gene Information

human ... DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356), HTR2C(3358)

Gene Information

human ... HRH1(3269)

Gene Information

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

Application

Thioridazine hydrochloride has been used as an intercalating agent for analyzing the integrity of double-stranded DNA (dsDNA) using square-wave voltammetry (SWV) techniques. Thioridazine hydrochloride has also been used as a positive control for the inhibition of hepatic enzyme cytochrome P4502D6 (CYP2D6) in human liver microsomes.

Biochem/physiol Actions

D2 dopamine receptor antagonist; phenothazine antipsychotic with reduced extrapyramidal side effects; Ca2+ channel blocker.

Preparation Note

250 mg of thioridazine hydrochloride is soluble in 5 ml of water and yields a clear, colorless to faint yellow solution. Thioridazine hydrochloride is also soluble in methanol, ethanol, and chloroform, but it is insoluble in ether.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves


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