All Photos(3)

T9250

Sigma-Aldrich

Thymidine

≥99%

Synonym(s):
Thymine deoxyriboside, 2′-Deoxythymidine, dT, 1-(2-Deoxy-β-D-ribofuranosyl)-5-methyluracil, 1-(2-Deoxy-β-D-ribofuranosyl)thymine
Empirical Formula (Hill Notation):
C10H14N2O5
CAS Number:
Molecular Weight:
242.23
Beilstein:
89285
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.51

Quality Level

biological source

synthetic (organic)

assay

≥99%

form

powder

mp

186-188 °C (lit.)

solubility

water: 50 mg/mL, clear, colorless

SMILES string

CC1=CN([C@H]2C[C@H](O)[C@@H](CO)O2)C(=O)NC1=O

InChI

1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m0/s1

InChI key

IQFYYKKMVGJFEH-XLPZGREQSA-N

Gene Information

human ... DTYMK(1841)

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General description

Thymidine is also referred to as pyrimidine deoxynucleoside. Deoxythymidine is a nucleoside present in DNA. In a DNA double stranded structure, thymidine pairs with deoxyadeninosine. It is useful in cell synchronization during S-phase. In the salvage pathway of pyrimidines, pyrimidine phosphorylase reversibly converts thymine to thymidine.

Application

Thymidine has been used:
  • as a supplement in HL5-modified medium for cell culture
  • to incubate cells in cell-cycle analysis
  • in cell synchronization

Packaging

1, 5, 10, 25 g in poly bottle

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Phosphorylation of Ku dictates DNA double-strand break (DSB) repair pathway choice in S phase
Lee KJ, et al.
Nucleic Acids Research, 44(4), 1732-1745 (2015)
Kif20a inhibition reduces migration and invasion of pancreatic cancer cells
Stangel D, et al.
The Journal of Surgical Research, 197(1), 91-100 (2015)
Molecular Biology, Principles of Genome Function: Biology, Molecular biology (2016)
Human Biochemistry and Disease, 571-571 (2008)
David Lam et al.
Biochemical and biophysical research communications, 363(3), 536-541 (2007-09-25)
How is one to investigate autophagic or necrotic cell death in the absence of interference from the apoptosis machinery? In the protist Dictyostelium, a model for the study of these two cell death types, we previously showed that autophagic cell...

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