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T9531

Sigma-Aldrich

D-(+)-Trehalose dihydrate

≥99% (HPLC), from Saccharomyces cerevisiae

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Synonym(s):
Trehalose dihydrate, α,α-Trehalose, α-D-Glucopyranosyl-α-D-glucopyranoside
Empirical Formula (Hill Notation):
C12H22O11 · 2H2O
CAS Number:
Molecular Weight:
378.33
Beilstein/REAXYS Number:
5322018
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.25

biological source

Saccharomyces cerevisiae

Quality Level

assay

≥99% (HPLC)

form

powder

optical activity

[α]20/D 174 to 182 °, c = 7% (w/v) in water

technique(s)

HPLC: suitable
PCR: suitable
cell based assay: suitable
cryopreservation: suitable

impurities

≤5.0% EtOH
<20 ppm Trace metals

color

white

mp

97-99  °C

solubility

water: 50 mg/mL, clear, colorless

application(s)

advanced drug delivery
agriculture
cell analysis
life science and biopharma
sample preparation

storage temp.

room temp

SMILES string

[H]O[H].[H]O[H].OC[C@H]1O[C@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C12H22O11.2H2O/c13-1-3-5(15)7(17)9(19)11(21-3)23-12-10(20)8(18)6(16)4(2-14)22-12;;/h3-20H,1-2H2;2*1H2/t3-,4-,5-,6-,7+,8+,9-,10-,11-,12-;;/m1../s1

InChI key

DPVHGFAJLZWDOC-PVXXTIHASA-N

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This Item
90210T0167625625
D-(+)-Trehalose dihydrate &#8805;99% (HPLC), from Saccharomyces cerevisiae

T9531

D-(+)-Trehalose dihydrate

D-(+)-Trehalose dihydrate suitable for microbiology, &#8805;99.0%, composed of two &#945;-glucose units that is used as a protectant, stabilizer and to support proper folding

90210

D-(+)-Trehalose dihydrate

D-(+)-Trehalose dihydrate from Saccharomyces cerevisiae, powder, BioReagent, suitable for cell culture, suitable for insect cell culture, &#8805;99%

T0167

D-(+)-Trehalose dihydrate

Trehalose, Dihydrate Non-reducing disaccharide which yields 2 moles of D-glucose upon acid hydrolysis. Inhibits polyglutamine-mediated protein aggregation both in vivo and in vitro.

625625

Trehalose, Dihydrate

assay

≥99% (HPLC)

assay

≥99.0% (HPLC)

assay

≥99%

assay

≥97.5% (by Assay)

technique(s)

HPLC: suitable, cell based assay: suitable, PCR: suitable, cryopreservation: suitable

technique(s)

-

technique(s)

cell culture | insect: suitable, cell culture | mammalian: suitable

technique(s)

-

solubility

water: 50 mg/mL, clear, colorless

solubility

H2O: 0.1 g/mL, clear, colorless

solubility

H2O: 50 mg/mL

solubility

water: 100 mg/mL

Quality Level

300

Quality Level

200

Quality Level

200

Quality Level

100

form

powder

form

powder

form

powder

form

solid

General description

Trehalose, also known as mycose or tremalose, is a nonreducing disaccharide of glucose commonly found in fungi, bacteria, and invertebrates. Its presence in these organisms highlights its significance in various biological processes and potential applications in biochemical research and cell culture studies.

Application

D-(+)-Trehalose dihydrate has been used:

  • as a transcription factor EB (TFEB) to study its effects on an autophagy-lysosomal system in human silicosis alveolar macrophages
  • as stabilizing excipient in spray-dried protein formulations
  • as a cryoprotectant to study its effects on mouse testicular cell suspensions

Biochem/physiol Actions

D-(+)-Trehalose shows anti-desiccant and cryopreservative activities. It acts as an osmolyte, and stress protectant and helps in the storage and transport of carbon. Trehalose is involved in the food, cosmetic, and pharmaceutical industries. It plays a vital role in the survival of certain insects and plants known as anhydrobionts during harsh environments such as high rates of dehydration.

Quality

Reduced metal ion content.

Preparation Note

Prepared by ion exchange chromatography.

Other Notes

For additional information on our range of Biochemicals, please complete this form.
To gain a comprehensive understanding of our extensive range of Disaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Customers Also Viewed

Slide 1 of 5

1 of 5

Trehalose production: exploiting novel approaches
Schiraldi C, et al.
Trends in Biotechnology, 20(10), 420- 425 (2002)
Shiyi Tan et al.
Life sciences, 257, 118043-118043 (2020-07-06)
Alveolar macrophages (AMs) are the primary targets of silicosis. Blockade of autophagy may aggravate the apoptosis of AMs. Trehalose (Tre), a transcription factor EB (TFEB) activator, may impact the autophagy-lysosomal system in AMs during silicosis. However, the mechanism by which
Experimental and theoretical electron density distribution of alpha,alpha-trehalose dihydrate
Stevens E D, et al.
Carbohydrate Research, 345(10), 1469-1481 (2010)
Trehalose metabolism in plants
Lunn J E, et al.
The Plant Journal, 79(4), 544-567 (2014)
Trehalose: current use and future applications
Ohtake S and Wang Y J
Journal of Pharmaceutical Sciences, 100(6) , 2020-2053 (2011)

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