This product is not guaranteed to be DNA-free, as no specification exists for this. It is recommended to perform a sensitive PCR on the product. Specific primers can be designed to amplify S. cerevisiae DNA, and a PCR reaction can be conducted using this product as the template. If no amplification occurs, it suggests that the reagent is DNA-free.
T9531
D-(+)-Trehalose dihydrate
≥99% (HPLC), from Saccharomyces cerevisiae
Synonym(s):
Trehalose dihydrate, α,α-Trehalose, α-D-Glucopyranosyl-α-D-glucopyranoside
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About This Item
Empirical Formula (Hill Notation):
C12H22O11 · 2H2O
CAS Number:
Molecular Weight:
378.33
UNSPSC Code:
12352201
NACRES:
NA.25
PubChem Substance ID:
EC Number:
202-739-6
Beilstein/REAXYS Number:
5322018
MDL number:
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InChI key
DPVHGFAJLZWDOC-PVXXTIHASA-N
InChI
1S/C12H22O11.2H2O/c13-1-3-5(15)7(17)9(19)11(21-3)23-12-10(20)8(18)6(16)4(2-14)22-12;;/h3-20H,1-2H2;2*1H2/t3-,4-,5-,6-,7+,8+,9-,10-,11-,12-;;/m1../s1
SMILES string
[H]O[H].[H]O[H].OC[C@H]1O[C@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O
biological source
Saccharomyces cerevisiae
assay
≥99% (HPLC)
form
powder
optical activity
[α]20/D 174 to 182 °, c = 7% (w/v) in water
technique(s)
HPLC: suitable, PCR: suitable, cell based assay: suitable, cryopreservation: suitable
impurities
≤5.0% EtOH, <20 ppm Trace metals
color
white
mp
97-99 °C
solubility
water: 50 mg/mL, clear, colorless
application(s)
advanced drug delivery
agriculture
cell analysis
life science and biopharma
sample preparation
storage temp.
room temp
Quality Level
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This Item | T9449 | T0167 | 90210 |
|---|---|---|---|
| biological source Saccharomyces cerevisiae | biological source Manihot esculenta root (Cassava) | biological source Saccharomyces cerevisiae | biological source - |
| technique(s) HPLC: suitable, cell based assay: suitable, PCR: suitable, cryopreservation: suitable | technique(s) HPLC: suitable | technique(s) cell culture | insect: suitable, cell culture | mammalian: suitable | technique(s) - |
| assay ≥99% (HPLC) | assay ≥99% (HPLC) | assay ≥99% | assay ≥99.0% (HPLC) |
| solubility water: 50 mg/mL, clear, colorless | solubility water: 50 mg/mL, clear, colorless to very faintly yellow | solubility H2O: 50 mg/mL | solubility H2O: 0.1 g/mL, clear, colorless |
| Quality Level 300 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| form powder | form powder | form powder | form powder |
Analysis Note
Reduced metal ion content.
Application
D-(+)-Trehalose dihydrate has been used:
Biochem/physiol Actions
D-(+)-Trehalose shows anti-desiccant and cryopreservative activities.[4] It acts as an osmolyte, and stress protectant and helps in the storage and transport of carbon.[5] Trehalose is involved in the food, cosmetic, and pharmaceutical industries.[6] It plays a vital role in the survival of certain insects and plants known as anhydrobionts during harsh environments such as high rates of dehydration.[7]
General description
Trehalose, also known as mycose or tremalose, is a nonreducing disaccharide of glucose commonly found in fungi, bacteria, and invertebrates. Its presence in these organisms highlights its significance in various biological processes and potential applications in biochemical research and cell culture studies.
Other Notes
For additional information on our range of Biochemicals, please complete this form.
To gain a comprehensive understanding of our extensive range of Disaccharides for your research, we encourage you to visit our Carbohydrates Category page.
Preparation Note
Prepared by ion exchange chromatography.
comparable product
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Experimental and theoretical electron density distribution of alpha,alpha-trehalose dihydrate
Stevens E D, et al.
Carbohydrate Research, 345(10), 1469-1481 (2010)
Trehalose: current use and future applications
Ohtake S and Wang Y J
Journal of Pharmaceutical Sciences, 100(6) , 2020-2053 (2011)
Trehalose production: exploiting novel approaches
Schiraldi C, et al.
Trends in Biotechnology, 20(10), 420- 425 (2002)
Shiyi Tan et al.
Life sciences, 257, 118043-118043 (2020-07-06)
Alveolar macrophages (AMs) are the primary targets of silicosis. Blockade of autophagy may aggravate the apoptosis of AMs. Trehalose (Tre), a transcription factor EB (TFEB) activator, may impact the autophagy-lysosomal system in AMs during silicosis. However, the mechanism by which
Trehalose metabolism in plants
Lunn J E, et al.
The Plant Journal, 79(4), 544-567 (2014)
Articles
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I am planning to use this in an assay that may involve the amplification of fungal DNA via PCR. Since this is derived from S. cerevisiae, how can I be sure that it is DNA free?
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How can I determine the shelf life / expiration / retest date of this product?
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If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdfHelpful?
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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