U104

UK 14,304

Name: UK 14,304
Brand: SIGMA

Synonym(s):

5-Bromo-N-(2-imidazolin-2-yl)-6-quinoxalinamine, 5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine, Brimonidine

Slide 1 of 1

Select a Size

Pricing and availability is not currently available.

About This Item

Empirical Formula (Hill Notation):

C₁₁H₁₀BrN₅

CAS Number:

59803-98-4

Molecular Weight:

292.13

MDL number:

MFCD00153878

UNSPSC Code:

12352200

PubChem Substance ID:

24277812

NACRES:

NA.77

Key Documents

View All Documentation

Quality Level

100

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: <0.8 mg/mL
DMSO: >6.5 mg/mL
ethanol: <8 mg/mL (warm)
H₂O: insoluble

SMILES string

Brc1c(NC2=NCCN2)ccc3nccnc13

InChI

1S/C11H10BrN5/c12-9-7(17-11-15-5-6-16-11)1-2-8-10(9)14-4-3-13-8/h1-4H,5-6H2,(H2,15,16,17)

InChI key

XYLJNLCSTIOKRM-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148), ADRA2A(150), ADRA2B(151), ADRA2C(152)

Looking for similar products? Visit Product Comparison Guide

Related Categories

Bioactive Small Molecule Agonists

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item	SML1184	S8822	SML2712
Sigma-Aldrich U104 UK 14,304	Sigma-Aldrich SML1184 OF-1	Sigma-Aldrich S8822 SB-525334	Sigma-Aldrich SML2712 ES9-17
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
solubility 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: <0.8 mg/mL, ethanol: <8 mg/mL (warm), DMSO: >6.5 mg/mL, H₂O: insoluble	solubility DMSO: 5 mg/mL, clear (warmed)	solubility DMSO: ≥20 mg/mL	solubility DMSO: 2 mg/mL, clear
Gene Information human ... ADRA1A(148), ADRA2A(150), ADRA2B(151), ADRA2C(152)	Gene Information -	Gene Information -	Gene Information -

Application

UK 14,304 has been used for the activation of extracellular signal-regulated kinase (ERK) in epicardial coronary artery culture[1]

UK 14,304 has been used in myenteric neurons to study the inhibition of R-type calcium currents[2]. UK 14,304 has also been used for immunofluorescence microscopy assays[3].

Biochem/physiol Actions

UK 14,304 is an α2-adrenoceptor agonist.[4] UK 14,304 inhibits hormone-sensitive lipase (HSL) activity and suppresses lipogenesis in adipose tissue.[5]

Features and Benefits

This compound is featured on the α2-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

UK 14,304 is soluble in 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin (<0.8 mg/mL), DMSO (>6.5 mg/ml) and ethanol (<8 mg/mL). However, it is insoluble in water.

pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Alpha 2-adrenergic receptors in the human cell line, HT29. Characterization with the full agonist radioligand [3H]UK-14,304 and inhibition of adenylate cyclase.

J T Turner et al.

Molecular pharmacology, 28(5), 422-430 (1985-11-01)

We have characterized the alpha 2-adrenergic receptor in membranes from the human colonic adenocarcinoma cell line, HT29, using the recently introduced alpha 2-agonist 5-bromo-6-[2-imidazolin-2-yl-amino]quinoxaline [( 3H]UK-14,304), two other radioligands, and a series of adrenergic agonists and antagonists. We also investigated

Alpha2-adrenoceptors couple to inhibition of R-type calcium currents in myenteric neurons.

X Bian et al.

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 19(10), 845-855 (2007-09-22)

Alpha2-adrenoceptors inhibit Ca2+ influx through voltage-gated Ca2+ channels throughout the nervous system and Ca2+ channel function is modulated following activation of some G-protein coupled receptors. We studied the specific Ca2+ channel inhibited following alpha2-adrenoceptor activation in guinea-pig small intestinal myenteric

Concurrent injection of dexamethasone intravitreal implant and anti-angiogenic agent in patients with macular edema: A retrospective cohort study.

Hung-Yu Lin et al.

Medicine, 96(47), e8868-e8868 (2018-02-01)

To evaluate the safety and efficiency in macular edema patients who concurrently received a single injection of a dexamethasone intravitreal implant (DEX, 0.7 mg) and ranibizumab (2.3 mg).A retrospective cohort study was conducted, and medical records from 2012 to 2016 were reviewed.

Mildly Cross-Linked Dendrimer Hydrogel Prepared via Aza-Michael Addition Reaction for Topical Brimonidine Delivery.

Juan Wang et al.

Journal of biomedical nanotechnology, 13(9), 1089-1096 (2018-02-27)

In this work, we developed a mildly cross-linked dendrimer hydrogel (mcDH) via

Effects of acute and chronic ethanol administration on the response of mouse adipose tissue hormone-sensitive lipase to alpha2-adrenoceptor activation by UK 14304.

Shih MF and Taberner PV

Alcohol and Alcoholism (Oxford, Oxfordshire), 36(5), 381-387 (2001)

View All Related Papers

Articles

α2-Adrenoceptors

Learn about alpha-2 adrenoceptor and its subtypes, mediated responses, and applications of agonists. Included is a list of available products and a comparison table.

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service