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MilliporeSigma

U2625

Uric acid

≥99%, crystalline

Synonym(s):

2,6,8-Trihydroxypurine

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25 G

$49.10

100 G

$166.00

1 KG

$1,100.00

$49.10


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About This Item

Empirical Formula (Hill Notation):
C5H4N4O3
CAS Number:
Molecular Weight:
168.11
UNSPSC Code:
12352005
NACRES:
NA.55
PubChem Substance ID:
EC Number:
200-720-7
Beilstein/REAXYS Number:
156158
MDL number:

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Product Name

Uric acid, ≥99%, crystalline

InChI key

LEHOTFFKMJEONL-UHFFFAOYSA-N

InChI

1S/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12)

SMILES string

O=C1NC(=O)C2=C(N1)NC(=O)N2

assay

≥99%

form

crystalline

mp

>300 °C (lit.)

Quality Level

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1 of 4

This Item
490997U2875NIST913B
Quality Level

100, 200

Quality Level

200

Quality Level

200

Quality Level

100

form

crystalline

form

solid

form

powder

form

crystalline (solid)

assay

≥99%

assay

99% (CP)

assay

11.0-13.0% anhydrous basis (Sodium, ICP)

assay

-

mp

>300 °C (lit.)

mp

>300 °C (lit.)

mp

-

mp

>300 °C (lit.)

Application

Uric acid has been used:
  • in inducing hyperuricemia in mice[1]
  • as a component of digestion fluid for the simulation of in vitro human digestion model[2]
  • in selectivity test of the glucose sensor in sweat-based diabetes monitoring [3]

Biochem/physiol Actions

Uric acid is an insoluble catabolite produced by adenine and guanine metabolism. Accumulation of uric acid leads to gout, hyperuricemia, arthritis and renal failure.[4] Elevated uric acid levels contributes to hypertension and pathogenesis of cardiovascular disease.[5][6] Low uric acid levels associated with Parkinson′s disease and multiple sclerosis, may elicit protective functionality.[6] High levels of uric acid in patients with chronic obstructive pulmonary disease (COPD) may serve as potential marker for diagnosis.[7]

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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A graphene-based electrochemical device with thermoresponsive microneedles for diabetes monitoring and therapy
Lee H, et al.
Nature Nanotechnology, 11(6), 566-566 (2016)
Uric acid in plants and microorganisms: Biological applications and genetics-A review
Hafez RM, et al.
Journal of Advanced Research, 8(5), 475-486 (2017)
Serum uric acid: a risk factor and a target for treatment?
Feig DI, et al.
Journal of the American Society of Nephrology, 17(4), S69-S73 (2006)
Reduction of Serum Uric Acid Associated with Attenuation of Renal Injury, Inflammation and Macrophages M1/M2 Ratio in Hyperuricemic Mice Model
HARYONO A, et al.
Kobe J. Med. Sci., 64(3), E107-E114 (2018)
Serum uric acid as a predictor of mortality and future exacerbations of COPD
Bartziokas K, et al.
The European Respiratory Journal, 43(1), 43-53 (2014)

Articles

Uric acid present in animal sera impacts serum-supplemented classical cell culture systems, influencing cell culture performance.

Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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