U2625

Sigma-Aldrich

Uric acid

≥99%, crystalline

Synonym(s):
2,6,8-Trihydroxypurine
Empirical Formula (Hill Notation):
C5H4N4O3
CAS Number:
Molecular Weight:
168.11
Beilstein/REAXYS Number:
156158
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.55

Quality Level

assay

≥99%

form

crystalline

mp

>300 °C (lit.)

SMILES string

O=C1NC(=O)C2=C(N1)NC(=O)N2

InChI

1S/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12)

InChI key

LEHOTFFKMJEONL-UHFFFAOYSA-N

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Application

Uric acid has been used:
  • in inducing hyperuricemia in mice
  • as a component of digestion fluid for the simulation of in vitro human digestion model
  • in selectivity test of the glucose sensor in sweat-based diabetes monitoring

Packaging

25, 100 g in poly bottle
1 kg in poly bottle

Biochem/physiol Actions

Uric acid is an insoluble catabolite produced by adenine and guanine metabolism. Accumulation of uric acid leads to gout, hyperuricemia, arthritis and renal failure. Elevated uric acid levels contributes to hypertension and pathogenesis of cardiovascular disease. Low uric acid levels associated with Parkinson′s disease and multiple sclerosis, may elicit protective functionality. High levels of uric acid in patients with chronic obstructive pulmonary disease (COPD) may serve as potential marker for diagnosis.

storage_class_code

11 - Combustible Solids

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

A graphene-based electrochemical device with thermoresponsive microneedles for diabetes monitoring and therapy
Lee H, et al.
Nature Nanotechnology, 11(6), 566-566 (2016)
Serum uric acid as a predictor of mortality and future exacerbations of COPD
Bartziokas K, et al.
The European Respiratory Journal, 43(1), 43-53 (2014)
Uric acid, hyperuricemia and vascular diseases
Jin M, et al.
Frontiers in Bioscience, 17, 656-656 (2012)
Serum uric acid: a risk factor and a target for treatment?
Feig DI, et al.
Journal of the American Society of Nephrology, 17(4), S69-S73 (2006)
Uric acid in plants and microorganisms: Biological applications and genetics-A review
Hafez RM, et al.
Journal of Advanced Research, 8(5), 475-486 (2017)
Articles
Uric acid is not a direct additive to any of the classical cell culture media. However, it is present in animal sera. Consequently, uric acid is typically present in complete serum-supplemented classical cell culture systems.
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