U3633
U 18666A
powder
Synonym(s):
(3β)-3-[2-(Diethylamino)ethoxy]androst-5-en-17-one hydrochloride
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About This Item
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assay
≥98% (HPLC)
form
powder
color
white to off-white
mp
195-196.5 °C (lit.)
solubility
H2O: 10 mg/mL≥
storage temp.
2-8°C
SMILES string
Cl[H].[H][C@@]12CC=C3C[C@H](CC[C@]3(C)[C@@]1([H])CC[C@]4(C)C(=O)CC[C@@]24[H])OCCN(CC)CC
InChI
1S/C25H41NO2.ClH/c1-5-26(6-2)15-16-28-19-11-13-24(3)18(17-19)7-8-20-21-9-10-23(27)25(21,4)14-12-22(20)24;/h7,19-22H,5-6,8-17H2,1-4H3;1H/t19-,20-,21-,22-,24-,25-;/m0./s1
InChI key
GZFYZYBWLCYBMI-MYZJJQSMSA-N
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This Item | 662015 | A8423 | U6881 |
---|---|---|---|
assay ≥98% (HPLC) | assay ≥95% (HPLC) | assay ≥98% | assay ≥98% (HPLC) |
form powder | form lyophilized solid | form powder | form powder |
storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. - |
solubility H2O: 10 mg/mL≥ | solubility water: 10 mg/mL | solubility - | solubility DMSO: soluble |
color white to off-white | color white | color - | color white |
mp 195-196.5 °C (lit.) | mp - | mp - | mp - |
General description
Application
- as a competitive inhibitor of the Niemann-Pick disease, type C (NPC2) binding partner Niemann-Pick C1 (NPC1) to treat symbiotic and aposymbiotic adult Aiptasia to study the effect of global sterol transport inhibition[3]
- in treating seminiferous tubules to study its effects on the localization pattern of VPS35-positive vesicles[4]
- to study the U18666A treatment effects on early endosomes and late endosomes/multivesicular bodies (MVBs)[4]
- as an NPC1 inhibitor to test its in vivo efficacy and study its effects on filovirus entry and infection[5]
Biochem/physiol Actions
Preparation Note
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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