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U4010

Sigma-Aldrich

Urokinase from human kidney cells

lyophilized powder

Synonym(s):

u-Plasminogen activator

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10000 UNITS
$298.00

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10000 UNITS
$298.00

About This Item

CAS Number:
9039-53-6
EC Number:
3.4.21.73 (BRENDA, IUBMB)
EC Number:
232-917-9
MDL number:
MFCD00132566
UNSPSC Code:
12352204
eCl@ss:
32160410
NACRES:
NA.54

$298.00

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form

lyophilized powder

mol wt

heavy chain 30,400 Da
light chain 2000 Da

storage temp.

2-8°C

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This Item
SRP3137T7513T4648
Urokinase from human kidney cells lyophilized powder

U4010

Urokinase from human kidney cells

PAI-2 human recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture

SRP3137

PAI-2 human

Thrombin from bovine plasma lyophilized powder, ≥2,000 NIH units/mg protein (E1%/280 = 19.5)

T7513

Thrombin from bovine plasma

Thrombin from bovine plasma lyophilized powder, 40-500 NIH units/mg protein (biuret)

T4648

Thrombin from bovine plasma

form

lyophilized powder

form

lyophilized

form

lyophilized powder

form

lyophilized powder

mol wt

heavy chain 30,400 Da, light chain 2000 Da

mol wt

60 kDa

mol wt

heavy chain ~33 kDa, light chain ~5 kDa

mol wt

heavy chain ~33 kDa, light chain ~5 kDa

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Quality Level

200

Quality Level

-

Quality Level

200

Quality Level

300

Application

Urokinase from human kidney cells has been used as a component of digestion mix for three-dimensional fibrin culture.[1] It has also been used in plasminogen activation assay.[2]

Biochem/physiol Actions

Urokinase is a protease that cleaves plasminogen to form plasmin. It binds to cell surface receptors (uPAR) from which it regulates cell adhesion and migration during tissue remodeling and which also activate intracellular signaling pathways. Urokinase is composed of three domains: the amino terminal domain which is homologous to epidermal growth factor is attached through a central kringle domain to the protease domain in the carboxyl terminus.
Urokinase was shown to augment proliferation of renal tumor cells. [3]

Physical properties

Supplied as a lyophilized powder containing human albumin, mannitol and NaCl.
The principle active ingredient is the low molecular weight form of urokinase, and consists of an A chain of 2,000 daltons linked by a sulfhydyl bond to a B chain of 30,400 daltons.

Other Notes

Note: Higher activities are obtained when human plasminogen is used as substrate.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H334

Hazard Classifications

Resp. Sens. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000333438
0000277763
SLCQ9581
SLCP1203
SLCM9837

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