U4133

URB597

≥98% (HPLC), powder

• Synonym(s): Cyclohexylcarbamic acid 3´-carbamoyl-biphenyl-3-yl ester
• Empirical Formula (Hill Notation): C₂₀H₂₂N₂O₃
• CAS Number: 546141-08-6
• Molecular Weight: 338.40
• MDL number: MFCD05863934
• PubChem Substance ID: 329827629
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white
• solubility: DMSO: soluble ~14 mg/mL
• storage temp.: 2-8°C
• SMILES string: NC(=O)c1cccc(c1)-c2cccc(OC(=O)NC3CCCCC3)c2
• InChI: 1S/C20H22N2O3/c21-19(23)16-8-4-6-14(12-16)15-7-5-11-18(13-15)25-20(24)22-17-9-2-1-3-10-17/h4-8,11-13,17H,1-3,9-10H2,(H2,21,23)(H,22,24)
• InChI key: ROFVXGGUISEHAM-UHFFFAOYSA-N

Description

General description

URB597 binds to active sites of fatty acid amide hydrolases and inhibits their activity. URB597 alters expression of tyrosine hydroxylase and interacts with abnormal-cannabidiol (Abn-CBD) and peroxisome proliferator-activated receptors (PPARs). URB597 elicits antinociception property via cannabinoid receptor by maintaining endocannabinoid anandamide (AEA) levels. URB597 reduces abnormal hyperactivity in neurons and could be for treatment of seizures and improving synaptic plasticity.

Biochem/physiol Actions

Potent, selective fatty acid amide hydrolase (FAAH) inhibitor.

Preparation Note

URB597 is soluble in DMSO at a concentration that is approximately 14 mg/ml.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves