U4884

Urea

Name: Urea
Brand: SIGMA

meets USP testing specifications

Synonym(s):

Carbamide, Carbonyldiamide

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About This Item

Linear Formula:

NH₂CONH₂

CAS Number:

57-13-6

Molecular Weight:

60.06

UNSPSC Code:

12352111

NACRES:

NA.75

PubChem Substance ID:

24900650

EC Number:

200-315-5

Beilstein/REAXYS Number:

635724

MDL number:

MFCD00008022

Assay:

98.0-102.0%

Key Documents

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InChI key

XSQUKJJJFZCRTK-UHFFFAOYSA-N

InChI

1S/CH4N2O/c2-1(3)4/h(H4,2,3,4)

SMILES string

NC(N)=O

agency

USP/NF, meets USP testing specifications

assay

98.0-102.0%

form

solid

dilution

(for analytical testing)

Quality Level

200

Gene Information

human ... CA1(759), CA2(760)
rat ... Ppm1a(24666)

mp

132-135 °C (lit.)

solubility

H₂O: soluble 480 g/L at 20 °C

density

1.335 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

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Biochemicals

Detergents - Anionic, Cationic, Zwitterionic, Anti-foaming

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Show Differences

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This Item	BP350	1.04166	NIST2141
Sigma-Aldrich U4884 Urea	BP350 Urea	SAFC 1.04166 Urea	NIST2141 Urea
application(s) pharmaceutical (small molecule)	application(s) pharmaceutical pharmaceutical small molecule	application(s) liquid formulation parenterals pharma/biopharma processes pharmaceutical	application(s) clinical testing
assay 98.0-102.0%	assay -	assay -	assay -
Quality Level 200	Quality Level -	Quality Level 500	Quality Level 100
solubility H₂O: soluble 480 g/L at 20 °C	solubility -	solubility -	solubility -
form solid	form solid	form granular	form crystals
mp 132-135 °C (lit.)	mp 132-135 °C (lit.)	mp 132-135 °C (lit.)	mp 132-135 °C (lit.)

Application

Used for the denaturation of proteins and as a mild solubilization agent for insoluble or denatured proteins. Useful for renaturing proteins from samples already denatured with 6 M guanidine chloride such as inclusion bodies. May be used with guanidine hydrochloride and dithiothreitrol (DTT) in the refolding of denatured proteins into their native or active form.

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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A unique role for p53 in the regulation of M2 macrophage polarization.

L Li et al.

Cell death and differentiation, 22(7), 1081-1093 (2014-12-20)

P53 is critically important in preventing oncogenesis but its role in inflammation in general and in the function of inflammatory macrophages in particular is not clear. Here, we show that bone marrow-derived macrophages exhibit endogenous p53 activity, which is increased

The 3' addition of CCA to mitochondrial tRNASer(AGY) is specifically impaired in patients with mutations in the tRNA nucleotidyl transferase TRNT1.

Florin Sasarman et al.

Human molecular genetics, 24(10), 2841-2847 (2015-02-06)

Addition of the trinucleotide cytosine/cytosine/adenine (CCA) to the 3' end of transfer RNAs (tRNAs) is essential for translation and is catalyzed by the enzyme TRNT1 (tRNA nucleotidyl transferase), which functions in both the cytoplasm and mitochondria. Exome sequencing revealed TRNT1

A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies.

Sreenivasa C Ramaiahgari et al.

Archives of toxicology, 88(5), 1083-1095 (2014-03-07)

Immortalized hepatocyte cell lines show only a weak resemblance to primary hepatocytes in terms of gene expression and function, limiting their value in predicting drug-induced liver injury (DILI). Furthermore, primary hepatocytes cultured on two-dimensional tissue culture plastic surfaces rapidly dedifferentiate

A mechanically and electrically self-healing supercapacitor.

Hua Wang et al.

Advanced materials (Deerfield Beach, Fla.), 26(22), 3638-3643 (2014-02-21)

Diagnosis of tuberculous meningitis by detection of tuberculostearic acid in cerebrospinal fluid.

G L French et al.

Lancet (London, England), 2(8551), 117-119 (1987-07-18)

Tuberculostearic acid, a structural component of Mycobacterium tuberculosis, was identified by gas chromatography/mass spectrometry with selected ion monitoring in cerebrospinal fluid (CSF) from 13 patients with proven and 8 out of 9 patients with suspected tuberculous meningitis; the negative result

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