UNC0638 hydrate

≥98% (HPLC)

2-Cyclohexyl-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy) quinazolin-4-amine
Empirical Formula (Hill Notation):
C30H47N5O2 · xH2O
Molecular Weight:
509.73 (anhydrous basis)
MDL number:
PubChem Substance ID:

Quality Level


≥98% (HPLC)



storage condition

protect from light




DMSO: >10 mg/mL

storage temp.


SMILES string




InChI key


General description

UNC0638 enhances the E-cadherin expression in gemcitabine-resistant cell line (PANC-1-R).


UNC0638 hydrate has been used:
  • in fractionation and isolation of human blood cells and cell nuclei
  • in the analysis of human immunodeficiency virus (HIV) reactivation in latently infected cell line
  • to determine the effect of G9a and its enzymatic activity on cisplatin resistance

UNC0638 has been used to block G9a (a lysine methyltransferase) function in C2C12 cells. UNC0638 has also been reported to decrease H3K9 dimethylation (H3K9me2) levels and inhibit cell death in hair cells.


5, 25 mg in glass bottle

Biochem/physiol Actions

UNC0638 hydrate is a histone methyltransferase (HMT) inhibitor. UNC0638 shows selectivity for G9a (EHMT2) and GLP (EHMT1) methyltransferases, which catalyze the methylation of lysine 9 of histone 3 (H3K9) as well as other non-histone substrates. For full characterization details, please visit the UNC0638 probe summary on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for epigenetic targets, visit

Features and Benefits

UNC0638 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.

Other Notes

UNC0638 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the UNC0638 probe summary on the Chemical Probes Portal website.


Skull and crossbones

Signal Word


Hazard Statements

Precautionary Statements


UN 2811 6.1 / PGIII

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Histone methyltransferase G9a drives chemotherapy resistance by regulating the glutamate-cysteine ligase catalytic subunit in head and neck squamous cell carcinoma
Liu CW, et al.
Molecular Cancer Therapeutics, molcanther-molcan0567 (2017)
G9a orchestrates PCL3 and KDM7A to promote histone H3K27 methylation
Pan MR, et al.
Scientific Reports, 5, 18709-18709 (2015)
HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency
Llewellyn GN, et al.
Journal of Neurovirology, 1-12 (2017)
Genome-wide mapping of histone H3K9me2 in acute myeloid leukemia reveals large chromosomal domains associated with massive gene silencing and sites of genome instability
Salzberg AC, et al.
PLoS ONE, 12(3), e0173723-e0173723 (2017)
Belinda Mei Tze Ling et al.
Molecular biology of the cell, 23(24), 4778-4785 (2012-10-23)
Sharp-1, a basic helix-loop-helix transcription factor, is a potent repressor of skeletal muscle differentiation and is dysregulated in muscle pathologies. However, the mechanisms by which it inhibits myogenesis are not fully understood. Here we show that G9a, a lysine methyltransferase...
Epigenetic modifications are thought to occur through two key interconnected processes—DNA methylation and the covalent modification of histones.
Read More
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